Methods: Clinician education was provided prior to study initiation. Patients aged 18 years and older who were discharged from the emergency department on a minimum of one oral antibiotic were screened for inclusion. Enrolled patients were contacted 10 days post discharge to determine outcomes.
Results: Two hundred thirty two patients were screened for inclusion and 57 patients had baseline data analyzed for intent-to-treat analysis. Of these, 26 patients had data available for outcomes analysis. Baseline characteristics were well matched between single and dual therapy groups, including co-morbidities, risk factors, and infection characteristics. For 46% of the patients reached at 10 days, clinical cure was achieved in 75% (9/12) of the single therapy group, and 79% (11/14) of the dual therapy group (p=0.99). Eight percent (1/12) of patients experienced an adverse event in the single therapy group compared to 50% (7/14) of patients in the dual therapy group (P=0.03).
Conclusion: Among patients discharged from the emergency department with a diagnosis of cellulitis, the addition of a second antibiotic targeting MRSA did not improve clinical cure and was associated with more adverse events.
E. Sullivan, None
H. Sikand, None
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