153. Human Parechovirus as an Important Cause of Central Nervous System Infection in Childhood
Session: Poster Abstract Session: Big Viruses in Little People (Pediatric Viral Diseases)
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • IDweek_poster_153.pdf (397.4 kB)
  • Background: Human parechovirus (HPeV) is an increasingly recognized pathogen as a cause of central nervous system (CNS) infection in neonates. However, HPeV infections have not been studied in older children beyond neonates. This study was performed to determine the prevalence of HPeV CNS infection and its clinical features in children from Korea.

    Methods: Reverse transcriptase-polymerase chain reaction (RT-PCR) assays were performed using HPeV-specific 5’ untranslated region (UTR)-targeted primers to detect HPeV in cerebrospinal fluid (CSF) samples of children who presented with fever or neurologic symptoms from January 1, 2013 to July 31, 2014. HPeV genotyping was performed by sequencing of the viral protein 3/1 (VP3/VP1) region. Clinical and laboratory data were abstracted from medical records retrospectively, and compared with those of enterovirus (EV)-positive patients from same period.

    Results: Of 102 CSF samples, HPeV was positive in 6 (5.9 %) and co-detected in 2 of 21 EV-positive samples. All the samples were typed as HPeV3. Two HPeV-positive patients were <3 months of age, but four others were over the age of 1 year. While HPeV-positive infants under 1 year-old presented with sepsis-like illness without definite neurologic abnomalities, HPeV-positive children over 1-year-old presented with fever and neurologic symptoms such as seizure, loss of consciousness, or gait disturbance. CSF findings of HPeV-positive patients were mostly within the normal range whereas majority (73.7 %) of EV-positive patients had pleocytosis.

    Conclusion: Although HPeV is typically associated with disease in young infants, this study suggests that HPeV is the emerging pathogen of CNS infection with neurologic symptoms in older childhood.

    Hyun Joo Jung, MD, Department of Pediatrics, Ajou University School of Medicine, Suwon, Korea, The Republic of, Joon Kee Lee, MD, Department of Pediatrics, Seoul National University Hospital, Seoul, Korea, The Republic of, Hee-Sup Kim, MD, Pediatrics, Dongkuk University Ilsan Hospital, Dongkuk University College of Medicine, Gyeonggi-do, Korea, The Republic of, Eun Hwa Choi, MD, PhD, Department of Pediatrics, Seoul National University Children's Hospital, Seoul, South Korea and Hoan Jong Lee, MD, PhD, Department of Pediatrics, Seoul National University College of Medicine, Seoul, South Korea

    Disclosures:

    H. J. Jung, None

    J. K. Lee, None

    H. S. Kim, None

    E. H. Choi, None

    H. J. Lee, None

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