Methods: We examined a total of 63 strains isolated from the respiratory apparatus samples of the different patients and conducted a retrospective investigation of the medical records of 15 patients who were determined to exhibit P. aeruginosa sensitivity. They were divided into high-tolerance MBCAD/MICAD (Over 32; n=9) and low-tolerance MBCAD/MICAD(Under 8; n=6) groups for further investigation.
Results: The findings indicated that the high-tolerance group included many severe cases with respiratory failure, and the imaging results showed that the disease was more extensive. Comparison of the bacterial basic data, high-tolerance group significantly upregulated the biofilm formation, elastase productions, pyoverdine production, swimming motility and swarming motility compared to low-tolerant group.
Conclusion: Conclusion: The present study clarified that the high-tolerance group comprised many patients with respiratory failure and refractory cases. Thus, tolerance level could be a prognostic marker for the chronic infection of P. aeruginosa, and furthermore, the development of a mechanism to suppress tolerance induction could be a target issue for new drugs to inhibit the progression of persistent P. aeruginosa infection.
Y. Miyake, None
Y. Nishioka, None