Urinary tract infection (UTI) is a common problem after renal transplantation. Our aim is to evaluate the incidence, risk factors and outcomes of UTIs and describe the resistance pattern among causative organisms in renal transplant recipients.
We conducted a retrospective cohort study of all patients who underwent renal transplantation between January 2012 and December 2014 at King Faisal Specialist Hospital in Jeddah, Saudi Arabia. Baseline characteristics and clinical and microbiological data were collected.
183 patients were followed for one year post renal transplantation. 163 patients received a kidney from living related donors and 20 patients received organs from deceased donors. The mean age of our cohort was 38 years (sd 14.8). During one year follow-up post transplantation, a total of 69 episodes of UTI were observed in 27 patients. The mean time to first UTI episode was 6.82 days (sd 8.1). A higher frequency of cystitis (74%) was observed compared to pyelonephritis. 14 patients had more than one episode of UTI during the first year post transplantation. The most common organisms were Klebsiella pneumonia (49%) followed by E.coli (26%) and Pseudomonas aeruginosa (7%). Extended spectrum beta lactamase (ESBL) producing Enterobacteriaceae were detected in 34 (49%) UTI episodes and carbapenem-resistant Enterobacteriaceae were detected in 7 episodes (10%). In univariate analysis, female gender was associated with the development of UTI post-transplant: OR 2.28 (95% CI (1.0-5.3) P=0.05). No mortality was observed in our cohort during one year follow up.
Female gender was associated with UTI post-transplant. In our cohort, a greater proportion of UTIs were caused by ESBL and carbapenemase producing Enterobacteriaceae compared to previous studies.
W. Habhab, None
E. Shabanah, None
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