235. The Diagnostic and Prognostic Value of Procalcitonin in Patients with The Diagnosis of SIRS, Sepsis and Septic Shock In Intensive Care Unit
Session: Poster Abstract Session: Diagnostics: Use of Biomarkers
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • poster 3.pdf (607.8 kB)
  • Background:

    It was aimed to evaluate the diagnostic and prognostic value of PCT in patients with the diagnosis of SIRS, sepsis and septic shock in intensive care unit.

    Methods:

    A prospective study was conducted on patients with SIRS, sepsis and septic shock in intensive care unit at a tertiary care center between December 2014-July 2015. Definitions were used according to the Surviving Sepsis Campaign, International Guideline, 2012. The PCT levels were compared to predict bacteremia and mortality.

    Results:

    A total of 156 patients were enrolled into the study. The study group was consisted of 64 (41%) bacteremic patients and the control group was consisted of 92 (59%) non-bacteremic patients. The overall mortality rate was 60.3%.

    Although PCT levels in the bacteremic group (11.9±21.5) were higher than non-bacteremic group (5.9±11.5), this difference was not significant (p=0.168).

    The mean levels of PCT in bacteremic patients with Gram-negative bacteria were 16.3±27.6, while Gram-positive bacteria was 7.3±10.7 (p=0.145).

    PCT levels in patients with intra-abdominal infection (14.6±24.6) were significantly higher than patients with the other infections (5.9±11.4) (p = 0.008).

    The mean PCT levels were significantly higher in non-survivors compared to survivors (10.1±18.0 vs 5.7±13.7; p=0.000).

    PCT, Charlson comorbidity index, APACHE II and SOFA score levels of patients with septic shock were significantly higher than the patients with SIRS and sepsis (Table 1). Significant correlation was found between SOFA score and PCT level (p=0.000).

    Conclusion:

    It can be speculated that PCT is a good predictor of mortality in patients with SIRS, sepsis and septic shock compared to other scoring systems in intensive care units. It can also be useful in early diagnosis and beneficial on follow-up of bacteremic patients.

     

    Table 1: Charlson index, APACHE II score, SOFA score, CRP and PCT levels in patients with septic shock

    SIRS and sepsis

    Septic Shock

    Mean±SS

    Min.-Max.

    Mean±SS

    Min.-Max.

    Charlson Index

    4,86±3,5

    0-12

    6,1±3,48

    0-15

    0,027

    APACHE II Score

    20,43±8,45

    4-36

    29,5±6,5

    15-42

    0,000

    SOFA Score

    7,48±4,05

    0-16

    11,4±3,21

    4-21

    0,000

    CRP

    16,94±9,74

    0,4-40,64

    19,21±9,5

    0,06-45,06

    0,112

    Procalcitonin

    3,55±6,39

    0,01-30,38

    14,29±22,36

    0,12-135,12

    0,000

    Tuna Demirdal, Dr, Pinar Sen, Dr and Atakan Nemli, Dr, Infectious Diseases, Izmir Katip Celebi University, Ataturk Training and Research Hospital, Izmir, Turkey

    Disclosures:

    T. Demirdal, None

    P. Sen, None

    A. Nemli, None

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