Methods: Using ICD-9 codes available in the National (Nationwide) Inpatient Sample, a nationally representative hospital discharge database, we estimated numbers of M-RH, IA-RH, HM-RH, HSCT-RH, and SOT-RH. US census data was used to calculate yearly overall M-RH rates and rates by sex and region. HM-RH, HSCT-RH, and SOT-RH were used to calculate M-RH and IA-RH rates occurring in conjunction with these conditions. Weighted least-squares technique was used on log transformed rates to test for linear trends and estimate average annual percent change (APC).
Results: The annual estimated number of M-RH rose from 485 in 2000 to 1080 in 2013; corresponding M-RH rates rose from 1.7 to 3.4 per one million persons (APC: +5.15%; p<0.001). Males had higher M-RH rates than females; the Northeast region had the lowest M-RH rates compared with the West, South, and Midwest. Among HM-RH, the M-RH rates increased (APC: +7.0% (p<0.0001), but IA-RH rates did not change significantly. There was no significant change in M-RH rates (APC: 2.0%, p=0.50) occurring among HSCT-RH, but a significant decline occurred in IA-RH rates (APC: ─4.6%; p=0.004). Among SOT-RH, M-RH rates (APC: +6.3%; p=0.04) and IA-RH rates (APC: +4.1%; p=0.0009) both increased over the study period.
G. Derado, None
R. K. Mody, None
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