Methods: This was a secondary data analysis of the Community-Acquired Pneumonia Organization (CAPO) International Cohort Study database. The intensity score was calculated as the sum of the number of days of each antibiotic multiplied by the antibiotic spectrum. The spectrum was translated into numeric values from 1 to 9 with increasing spectrum.
Results: A total of 772 patients were included in the study, 401 with an unknown etiology and 371 with a known etiology. The median antibiotic intensity score (IQR) was 60 (54) for those with a known etiology, and 55 (48) for those with an unknown etiology (P=0.33).
Conclusion: This study indicates that there is no difference in antibiotic exposure for patients with CAP when a pathogen is identified or not. Our data suggest that current clinical practice is to manage patients with broad-spectrum antibiotics without performing pathogen-directed therapy once an etiology of CAP has been identified. The influence of an effective antimicrobial stewardship program should impact this practice.
T. Wiemken, None
R. Kelley, None
A. Raghuram, None
S. Bhandary, None
A. Babiker, None
J. Bordon, None
T. M. File Jr., None
J. Ramirez, None
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