Methods: This was a secondary data analysis of the Community-Acquired Pneumonia Organization (CAPO) international cohort study database. Log-binomial regression was used to determine the adjusted impact of obesity on mortality.
Results: A total of 1,343 patients with normal BMI and 1,446 with increased BMI (obese) were included in the study. After adjusting for confounding factors, there was a 27% decreased risk of 30-day mortality for obese patients compared to those with a normal BMI.
Conclusion: This study indicates that obesity is protective for mortality in hospitalized patients with CAP. Our data are in agreement with two recent publications indicating that obese patients with CAP have improved survival. Obese patients have an exaggerated inflammatory state at baseline that may be protective during an episode of CAP. A clear understanding of the protective effect of obesity on mortality may help to define new therapeutic strategies.
A. Raghuram, None
F. Arnold, None
T. Wiemken, None
J. Chalmers, None
M. I. Restrepo, None
J. Bordon, None
S. Aliberti, None
J. Ramirez, None
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