Methods: This retrospective, observational cohort study included susceptibility data from all CF respiratory cultures collected from patients with a confirmed CF diagnosis over a 6-year period (January 2010- December 2015) at two children’s hospital sites (located 35 miles apart) and their parent institutions. CF antibiograms were developed for each site and compared to their respective hospital-wide antibiograms.
Results: A total of 1220 cultures were collected from 138 patients with CF. There was a significant difference between the two CF Centers in the mean patient age (Site 1: 26.8 ± 12.7 vs Site 2: 11.8 ± 7.3; p <0.0001). Pseudomonas aeruginosa, MSSA, and MRSA were the most prevalent organisms identified. Significant differences in MRSA were observed in the CF vs hospital antibiograms at each of the two sites (Site 1: 23% vs 36%, p <0.001; Site 2: 16.5% vs 40%, p < 0.0001). Pseudomonas aeruginosa exhibited significantly increased resistance for all antimicrobials at the 1st CF Center site compared to its parent institution (p <0.0001), however, this was not observed at the 2nd CF Center site.
Conclusion: Due to differences in susceptibilities between CF and hospital-wide antibiograms, customized CF antibiograms are warranted to guide optimal empiric antimicrobial therapy and promote antimicrobial stewardship.
D. Angst, None
S. M. Wieczorkiewicz, None
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