2347. Risk factors associated with Adenovirus Infection in Solid Organ Transplant Recipients
Session: Poster Abstract Session: Transplant Virology
Saturday, October 29, 2016
Room: Poster Hall
  • Majorant poster IDSA final procente.pdf (1.9 MB)
  • Title: Risk factors associated with Adenovirus Infection in Solid Organ Transplant Recipients

    Denisa Majorant, Fang Qiu, Andre Kalil, Natasha Wilson, Jonathan Tefft, Diana F Florescu

    Key words: Adenovirus, solid organ transplant, shedding, infection

    Background: Adenoviruses (ADV) have emerged as an important pathogen in immunocompromised hosts. The study aimed to assess risk factors and outcomes with ADV infections in the solid organ transplant recipients.

    Methods: This was a retrospective cohort study solid organ transplant patients who tested positive for ADV between 01/01/2004 and 03/12/2014. The patients were divided in 2 groups: patients with ADV shedding and patients with ADV infection. The characteristics and outcomes of the patients were compared using Wilcox rank – sum and Fisher exact test. Logistic regression was performed to identify risk factors.

    Results: We included125 patients, mean age: 9.79 years (standard deviation 16.54); males: 49.6%. Adenovirus infection was diagnosed in 20.8% of the patients, while 78.2% had just adenovirus shedding. Table 1 below describes the demographics.

    Table 1.

    The results of the univariate analysis for the risk factors for ADV infection are in table 2.

    Table 2

    Mortality in patients with shedding vs. patients with infection was: 26.92% vs. 6.06 % (p=0.006) at one year post-transplantation, while it was38.46 % vs.11.11 % (p=0.002) at one year post ADV positive testing.

    Conclusion:  The study results did not reveal an independent risk factor for ADV infection. Compared to ADV shedding, the patients with ADV infection had a significant higher mortality.

    Denisa Majorant, MD1, Fang Qiu, PhD2, Andre C. Kalil, MD, MPH, FIDSA1, Natasha Wilson, RN1, Jonathan Tefft, Clinical Research Associate1 and Diana F. Florescu, MD1, (1)Infectious Diseases, University of Nebraska Medical Center, Omaha, NE, (2)Biostatistics Department, Nebraska Medical Center, Omaha, NE


    D. Majorant, None

    F. Qiu, Chimerix: Investigator , Research grant

    A. C. Kalil, None

    N. Wilson, Chimerix: Investigator , Research grant

    J. Tefft, Chimerix: Collaborator , Research grant

    D. F. Florescu, Chimerix: Investigator , Research grant

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