1286. Respiratory Syncytial Virus Infections in a Pediatric Intensive Care Unit in Japan
Session: Poster Abstract Session: Clinical Infectious Diseases: Respiratory Infections
Friday, October 28, 2016
Room: Poster Hall
Posters
  • IDweek poster最終版.pdf (816.5 kB)
  • Background: 

    Respiratory syncytial virus (RSV) infections frequently result in mild to severe respiratory infections in children. Although symptomatic therapy is the norm, admission to a pediatric intensive care unit (PICU) is not uncommon. The aim of our study was to evaluate the clinical differences between RSV subtypes and factors associated with severity in PICU.

    Methods: 

    RSV infected children seen at the PICU at Tokyo Metropolitan Children’s Medical Center between April 2012 and March 2016 were included in our study. To test for RSV subtypes A and B, children were swabbed nasally and the samples were analyzed using real-time polymerase chain reaction (PCR). Co-infections were also tested for other respiratory viruses by real-time PCR. The following data were collected: patients’ demographic data, the pediatric index of mortality 2 (PIM2) score, underlying diseases, microbiological results, length of PICU admission, length of mechanical ventilation, and outcomes. RSV subtypes and PIM 2 score ≧1 (the severe group) and <1 (the non-severe group) were compared.

    Results: 

    Seventy one children were infected with RSV. Forty three (60.6%) were boys. The median age was 9 months old (interquartile range 2-27 months old). Among them, 57 (80.3%) received mechanical ventilation. RSV serotypes A and B were 46 (64.8%) and 25 (35.2%), respectively. Underlying diseases were identified in 35 (49.3%), and co-infections were identified in 31 (43.7%) patients. The median duration of ventilation was 6 days (interquartile range 2-8 days) and the median length of PICU admission was 8 days (interquartile range 3-10 days). There was one mortality at 30 days post admission. There was no clinical difference between RSV serotypes A and B. Multivariate analysis showed that severity was related to co-infection (p=0.02).

    Conclusion: 

    There was no clinical difference between RSV subgroups A and B in the PICU patients. Co-infection was found to be related to severity of RSV infections.

    Yoshiaki Cho, MD1, Takemi Murai, MD, PhD1, Yukitsugu Nakamura, MD, PhD1, Takayuki Yamanaka, MD1, Kahoru Fukuoka, MD1, Hiroki Sakurai, MD1, Yuta Aizawa, MD, PhD1, Mihoko Isogai, MD1, Yuho Horikoshi, MD1 and Kazue Kinoshita, MS2, (1)Infectious Diseases, Tokyo Metropolitan Children's Medical Center, Tokyo, Japan, (2)Molecular Laboratory, Tokyo Metropolitan Children' s Medical Center, Fuchu, Japan

    Disclosures:

    Y. Cho, None

    T. Murai, None

    Y. Nakamura, None

    T. Yamanaka, None

    K. Fukuoka, None

    H. Sakurai, None

    Y. Aizawa, None

    M. Isogai, None

    Y. Horikoshi, None

    K. Kinoshita, None

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