603. Zika Virus Infection in a Non Mosquito-Borne Transmission Country
Session: Poster Abstract Session: Oh One World: Infections from Near and Far
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • Poster IDWEEK 2016-DEF.pdf (674.4 kB)
  • Background: Zika virus was introduced to the Americas in 2014. More than 700.000 autochthonous cases in 35 countries have occurred with important complications. Chile hasn´t got mosquito-borne transmission of Zika virus so far. The aim of this study was to describe demographic and clinical features of Zika virus infection in Chilean patients.

    Methods: Patients with positive Zika test in our Diagnostic Virology Laboratory where invited to participate. They signed a consent form and a survey questionnaire with demographic and clinical information was completed. Zika diagnosis was performed by either RT-PCR (in house real time PCR with CDC protocol) or Zika IgM – IgG (ELISA comercial test from Euroimmune®)

    Results: Twelve patients tested positive, average age 31.4 (15-51 years), 7 females. Ten patients answered the questionnaire. Nine were imported cases with mosquito-borne transmission (1 pregnant woman) and 1 locally acquired by sexual transmission. Country of exposure was Brazil 3, Venezuela 3, Colombia 2, Haiti 1 and Chile 1 (sexually transmitted). Onset of symptoms occurred between 1 day before and 9 days after returning to Chile. The sexually transmitted case was from a symptomatic male to his female partner. The interval between sexual intercourses and the onset of symptoms was between 6-12 days. Average duration of the travel was 11 days (3-21 days). Main symptoms were maculopapular rash in 8/10, itching rash 7/8, conjunctivitis 8/10, Fever 9/10 with an average temperature of 38,1°C (37,5-38,8°C) lasting 3 days (1-7 days), arthritis 6/10 (duration 3-15 days), joints involved were hands, elbows and knees, headache in 8/10 patients, retro auricular swollen lymph nodes were present in 6/10 patients and 2 patients presented gastrointestinal symptoms. No hospitalizations were required. The pregnant woman was in her 28Thweek of gestation at onset of symptoms and diagnosis was performed 2 months later with positive Zika IgM ang IgG serology. Newborn was asymptomatic, with negative Zika RT-PCR and positive IgG and negative IgM at birth. She has normal cerebral ultrasound and follow up serology shows a decrease in IgG title.

    Conclusion: Zika virus infection is present in Chilean travelers, but also has to be included in the differential diagnosis of all patients with suspected symptoms mainly itchy rash, and had contact with travelers to endemic areas.

    Cecilia Vizcaya, MD1, Cecilia Perret, MD1, Constanza Martinez-Valdebenito, Bs2, Marcela Ferres, MD, MPH3, Ana Maria Contreras, MT3 and Jeannette Dabanche, MD4, (1)Pediatrics, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, (2)Infectious Disease and Immunology, Pontificia Universidad Catolica, Santago, Chile, (3)Virology Laboratory, Escuela de Medicina, Pontificia Universidad Católica de Chile, Santiago, Chile, (4)Hospital Militar de Santiago, Santiago, Chile

    Disclosures:

    C. Vizcaya, None

    C. Perret, None

    C. Martinez-Valdebenito, None

    M. Ferres, None

    A. M. Contreras, None

    J. Dabanche, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.