731. Effectiveness of Stepwise Perinatal Immunization Education: A Cluster Randomized Controlled Trial
Session: Poster Abstract Session: Vaccines: Improving Delivery
Thursday, October 27, 2016
Room: Poster Hall
Background:  Perinatal immunization education plays an important role to improve infants’ immunization outcome; however, the contents of education materials at each perinatal period have not been fully evaluated. We hypothesized that stepwise education offered at different perinatal period impacts on the immunization status of infants and enhances maternal immunization knowledge.

Methods: This two-arm, pair-matched, cluster-randomized controlled trial recruited pregnant women from nine obstetric sites in Niigata, Japan. The intervention group received a stepwise, interactive educational intervention (prenatally, postnatally, and 1 month after birth). The control group received a leaflet containing general information on immunization. The infants’ immunization status was evaluated at age six months and maternal immunization knowledge, attitudes and beliefs were evaluated by a written survey after each intervention.

Results:  Among the 188 study participants, 151 (80.3%) replied to the final post-survey. At six month of age, the percentages of children who completed three doses of inactivated polio, diphtheria, tetanus toxoid, acellular pertussis (DTaP-IPV) vaccine was higher in the intervention groups than in the control (P=0.04); however, no difference was observed in Haemophilus influenzae type b (Hib) (P=0.67) vaccine and 13-valent pneumococcal conjugate vaccine (PCV13) (P=0.20). Duration to completion of the third dose of DTaP-IPV, Hib vaccines, and PCV13 was shorter in the intervention group than in the control (P=0.03, P<0.01, P<0.01, respectively). Furthermore, a significant improvement of knowledge score was observed in the intervention group over time compared to the control group (P=0.02).

Conclusion: Stepwise perinatal immunization education improved immunization schedule adherence and enhanced maternal immunization knowledge.

Aya Saito, RN, PHN, MSN, PhD, The University of Tokyo, Tokyo, Japan, Akihiko Saitoh, MD, PhD, Infectious Disease, National Center for Child Health and Development, Tokyo, Japan, Isamu Sato, M.D., Ph.D., Yoiko Pediatric Clinic Sato, Niigata, Japan, Tomohiro Shinozaki, M.P.H., Graduate School of Medicine, The University of Tokyo, Tokyo, Japan, Hajime Kamiya, MD, MPH, PhD, Infectious Disease Surveillance Center, National Institute of Infectious Diseases, Tokyo, Japan and Satoko Nagata, RN, PHN, PhD, Department of Community Health Nursing, The University of Tokyo, Tokyo, Japan


A. Saito, None

A. Saitoh, None

I. Sato, None

T. Shinozaki, None

H. Kamiya, None

S. Nagata, None

Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.