Methods: This two-arm, pair-matched, cluster-randomized controlled trial recruited pregnant women from nine obstetric sites in Niigata, Japan. The intervention group received a stepwise, interactive educational intervention (prenatally, postnatally, and 1 month after birth). The control group received a leaflet containing general information on immunization. The infants’ immunization status was evaluated at age six months and maternal immunization knowledge, attitudes and beliefs were evaluated by a written survey after each intervention.
Results: Among the 188 study participants, 151 (80.3%) replied to the final post-survey. At six month of age, the percentages of children who completed three doses of inactivated polio, diphtheria, tetanus toxoid, acellular pertussis (DTaP-IPV) vaccine was higher in the intervention groups than in the control (P=0.04); however, no difference was observed in Haemophilus influenzae type b (Hib) (P=0.67) vaccine and 13-valent pneumococcal conjugate vaccine (PCV13) (P=0.20). Duration to completion of the third dose of DTaP-IPV, Hib vaccines, and PCV13 was shorter in the intervention group than in the control (P=0.03, P<0.01, P<0.01, respectively). Furthermore, a significant improvement of knowledge score was observed in the intervention group over time compared to the control group (P=0.02).
Conclusion: Stepwise perinatal immunization education improved immunization schedule adherence and enhanced maternal immunization knowledge.
I. Sato, None
T. Shinozaki, None
H. Kamiya, None
S. Nagata, None