85. Neurologic complications of Zika Virus Infection: Prospective Descriptive Study of 52 Patients Attended at the Hospital Universitario de Caracas between January and April 2016.
Session: Oral Abstract Session: Vectors and Viruses
Thursday, October 27, 2016: 8:45 AM
Room: 283-285
Background: Zika virus infection is an emergent disease, considered as an international public health emergency, with devastating neurologic complications. In Venezuela between December 12th 2015 and February 13th 2016, 578 Guillain–Barre Syndrome (GBS) cases were notified. From these, 235 reported symptoms related to Zika virus infection. The previous reported annual incidence was 1-2 cases/100.000 inhabitants. In the last four months the increase was remarkable. Objective: To describe the neurologic complications of Zika virus infection, evaluated between January and April 2016 at the Neurology Service and Intensive Care Unit, Hospital Universitario de Caracas (HUC), Venezuela. Clinical characterization and severity of each case are established. Patients were stratified regarding age, sex, geographic origin and complications.

Methods: Epidemiologic and clinical information was collected in a data base. A descriptive analysis was performed.

Results: Of the 52 patients: 31 female, 21 male. Age distribution: 5 patients were < 15 years old, 5 between 15 - 30, 6 between 30 - 40, 12 between 40 - 50, 10 between 50 - 60, and 12 > 60. Patients came from Caracas (25 cases), Miranda State (19 cases), La Guaira (5 cases), Guarico, Amazonas, Portuguesa and Nueva Esparta 1 case each. From the 52 patients, 44 were diagnosed with GBS, 4 Transverse Myelitis, 3 meningoencephalitis and 1 optic neuritis. Neurologic characterization: 29 patients had areflexia, 9 hyporeflexia, 4 transverse myelitis with hyperactivity of muscle stretch reflexes. In 37 cases facial diplegia was present. Unilateral facial nerve palsy was observed in 8 patients. 7 patients had no facial nerve component. The 21 patients who required mechanic ventilation had comorbidities such as infection and hematologic complications. 8 patients died. Treatment: 20 patients were treated with Intravenous Immunoglobulin (IVIG). 9 Plasmapheresis, 4 plasmapheresis followed by IVIG and 19 received no treatment.

Conclusion: Neurologic complications of Zika virus infection include GBS, Transverse Myelitis, meningoencephalitis and optic neuritis. A significant increase in the number of cases occurred between December 2015 and February 2016. Severe forms of these complications lead to sequelae and death.

Ydarlys Yate, MD1, Elizabeth Armas, MD1, Nathaly Atencio, MD1, Krikor Postalian, MD1, Louwis Perez, MD2, Francisco Chacon, MD2, Clara Pacheco, MD2, Maria Redondo, MD3 and Maria Landaeta, MD MSc4, (1)Neurology, Hospital Universitario de Caracas, Caracas, Venezuela (Bolivarian Republic of), (2)Intensive Care, Hospital Universitario de Caracas, Caracas, Venezuela (Bolivarian Republic of), (3)Infectious Diseases, Hospital Universitario de Caracas, Caracas -Miranda state, Venezuela, Bolivarian Republic o, (4)Infectious Diseases, Hospital Universitario de Caracas, Caracas, Venezuela

Disclosures:

Y. Yate, None

E. Armas, None

N. Atencio, None

K. Postalian, None

L. Perez, None

F. Chacon, None

C. Pacheco, None

M. Redondo, None

M. Landaeta, None

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