Methods: Patients of the pediatric oncology and BMT unit admitted between May 2014 and December 2015 at our institution and developed infections were analyzed.
Results: We identified 360 infections in 424 patients in 1,594 admissions in oncologic pediatric unit, and 6 infections in 14 patients admitted in the BMT unit. The infection rate among pediatric patients with cancer was 22.6/100 admissions and 43/100 among pediatric patients undergoing to BMT. Episodes of febrile neutropenia presented in 67% (291/424) of children with cancer. In the oncologic unit, bloodstream infections (BSI) were the most common (119 episodes, 33.1%), followed by pneumonias (107 episodes, 30%) and urinary tract infections (55 episodes, 15.3%). In the BMT unit, BSIs associated to catheters were most prevalent (6 episodes, 43%). Together, oncologic and BMT patients, Gram-negative infections were seen in 83 (70%) patients with BSI, followed by Gram-positive infection in 48 (40.3%), and fungi in 7 (6%) cases. Pseudomonas aeruginosa and Escherichia coliwere the most common Gram-negative pathogens and coagulase negative staphylococci were the most common Gram-positive microorganisms isolated. Infection-associated mortality rate among pediatric oncology patients was 9.4% (34/360), and among children undergoing to BMT was 22.2% (2/9).
Conclusion: The high rates of infection and infectious mortality among oncologic patients and BMTs require further studies to identify risk factors. Identified risk factors must be addressed to improve better survival rates of children cancer and BMT in our hospital.
O. Gonzalez-Ramella, None
F. Sanchez, None
M. Caniza, None
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