1101. Predictive Factors associated with Stenotrophomonas maltophilia bacteremia infected by Antibiotic-resistant strains
Session: Poster Abstract Session: Clinical Infectious Diseases: Bacteremia and Endocarditis
Friday, October 28, 2016
Room: Poster Hall
Background: Stenotrophomonas maltophilia is an important nosocomial pathogen. This pathogen has intrinsic or acquired resistance to a number of antibiotics classes. Also, Stenotrophomonas infections have been associated with high mortality, mainly immunocompromised patients. Accordingly, we conducted a retrospective cohort study on the clinical data, microbiological characteristics and outcomes of patients with S. maltophilia bacteremia.

Methods: A retrospective cohort study was conducted at two tertiary care referral hospitals in Seoul, South Korea. Data were collected between January 2006 and December 2014 from electric medical records. Analysis was performed to identify risk factors associated with 30-days mortality, and predictive factors of antibiotic-resistant strains.

Results: In total, 128 bacteremia patients were enrolled in the study. The 30-day mortality rate was 64.1%. In multivariable analysis, hypoalbuminemia (odds ratio [OR], 3.018; 95% confidence interval [CI], 1.174-7.758; P = 0.022), hematologic malignancy (OR, 12.062; 95% CI, 1.301-111.824; P = 0.028), and antibiotics-resistant strain (OR, 2.510; 95% CI, 1.057-5.959; P = 0.037) were independent risk factors for mortality. Analysis of predictive factors for S. maltophilia bacteremia with antibiotics-resistant strain was performed. Based on this multivariate analysis, Chalson comorbidity index (OR, 1.313; 95% CI, 1.062-1.623, P=0.012) and indwelling of a central venous catheter (CVC) (OR, 5.371; 95% CI, 1.092-26.414, P=0.039) were independent predisposing factors associated with antibiotic-resistant strain of S. maltophilia infection.

Conclusion: Our findings suggest that high Chalson comorbidity score and indwelling of a CVC was significantly independent predictors of S. maltophilia bacteremia patients with antimicrobial resistant strain. Therefore, we need carefully to consider antibiotics use of patients with S. maltophilia bacteremia who have certain predictive factors.

Eun Jin Kim, MD1,2, Moo Hyun Kim, MD1, Woo Yong Jeong, MD1, In Young Jung, MD2,3, Yong Chan Kim, MD3,4, Dong Hyun Oh, MD2,3, Je Eun Song, MD2,3, Nam Su Ku, MD3,4, Jun Yong Choi, MD, PhD3,4, Young Goo Song, MD, PhD3,4, June Myung Kim, MD, PhD3,4 and Su Jin Jeong, MD/PhD3,4, (1)Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea, The Republic of, (2)AIDS Research Institute, Yonsei University college of Medicine, Seoul, Korea, The Republic of, (3)Department of Internal Medicine, Yonsei University College of Medicine, Seoul, South Korea, (4)AIDS Research Institute, Yonsei University College of Medicine, Seoul, South Korea

Disclosures:

E. J. Kim, None

M. H. Kim, None

W. Y. Jeong, None

I. Y. Jung, None

Y. C. Kim, None

D. H. Oh, None

J. E. Song, None

N. S. Ku, None

J. Y. Choi, None

Y. G. Song, None

J. M. Kim, None

S. J. Jeong, None

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