2140. HIV-infection is Associated with Biomarkers of Endothelial Injury Among Virally Suppressed Adults
Session: Poster Abstract Session: HIV Cardiovascular Disease, Lipids, and Diabetes
Saturday, October 29, 2016
Room: Poster Hall
Background:  HIV infection is associated with excess cardiovascular disease (CVD). However, the degree of endothelial injury and its association with future risk for CVD have not been studied in sub-Saharan Africa (SSA).

Methods:  We enrolled 83 HIV-uninfected and 111 treated and virally suppressed HIV-infected adults from a study on CVD risk among HIV-infected patients in Botswana. We collected data on known cardiovascular risk factors [CVD-RF] and treatment status (age, sex, body mass index, mean arterial pressure, total cholesterol, glycosylated haemoglobin, cigarette smoking and statin use) and tested for vascular adhesion molecule 1 (VCAM-1), intercellular adhesion molecule 1 (ICAM-1), and e-selectin. The association between each biomarker (log-transformed if skewed) and HIV-status was explored using linear regression analysis after controlling for CVD-RF. The association between each biomarker and CVD risk score was assessed using the ASCVD risk score (10-year risk <7.5% vs. ≥7.5%) using logistic regression analysis.

Results:  HIV-infected participants were median 39 years (51% female); HIV-uninfected were median 38 years (45% female). HIV-infected participants had significantly higher VCAM-1 than HIV-uninfected participants (log 6.6 versus 6.5ng/ml, p<0.01) but not ICAM-1 (487.1 versus 447.5ng/ml, p=0.08), or e-selectin (61.6 versus 59.4ng/ml, p=0.06). In multivariate analysis, being HIV-infected was significantly associated with increased VCAM-1 (p<0.01) and ICAM-1 (p=0.03) but not e-selectin. However, HIV-status mediated the relationship between e-selectin and CVD-RF: among HIV-uninfected persons, higher BMI & current smoking were associated with higher e-selectin (p=0.03, p=0.02), but these factors were not significantly associated with e-selectin in HIV-infected individuals (p=0.25 & p=0.86 respectively). None of these biomarkers were associated with ASCVD risk score.

Conclusion:  HIV-status was associated with markers of endothelial injury in adults in Botswana. However, in this relatively small study, these biomarkers were not associated with excess CVD risk based on the ASCVD risk score.

Mosepele Mosepele, MD, MSc1, Tommy Palai, MD2, Lucy Mupfumi, MSc3, Terence Mohammed, MSc3, Kara Bennett, MSc4, Shahin Lockman, MD, MSc3,5 and Virginia Triant, MD, MPH6, (1)Internal Medicine, University of Botswana, Faculty of Medicine, Gaborone, Botswana, (2)Internal Medicine, University of Botswana Faculty of Medicine, Gaborone, Botswana, (3)Botswana-Harvard AIDS Partnership, Gaborone, Botswana, (4)Bennett Statistical Consulting Inc, Ballston Lake, NY, (5)Infectious Disease & Immunology, Harvard T. H. Chan School of Public Health, Boston, MA, (6)Infectious Diseases / General Medicine, Massachussetts General Hospital / Harvard Medical School, Boston, MA

Disclosures:

M. Mosepele, None

T. Palai, None

L. Mupfumi, None

T. Mohammed, None

K. Bennett, None

S. Lockman, None

V. Triant, None

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