620. First Three-Year Experience of Severe Fever with Thrombocytopenia Syndrome in South Korea
Session: Poster Abstract Session: Oh One World: Infections from Near and Far
Thursday, October 27, 2016
Room: Poster Hall
Background: Severe fever with thrombocytopenia syndrome (SFTS) is an emerging infectious disease which is endemic in China, South Korea and Japan. The case-fatality of SFTS is high, but the literature for SFTS outside China is small. The object of the study was to evaluate the overall characteristics of SFTS in South Korea since its first report in 2013.

Methods: The subjects were all SFTS patients reported to the Korea Centers for Disease Control and Prevention from 2013 to 2015 who were confirmed either genotypic or serologic methods. Nationwide SFTS Clinical Network was formed and retrospectively collected clinical information. The epidemiologic and clinical characteristics of SFTS were analyzed, and risk factors leading to the death of SFTS patients were sought.

Results: Total 172 SFTS patients were confirmedfor three years in South Korea. Two patients were diagnosed outside a reference laboratory. SFTS occurred all over the country except for urban areas, but hilly area in eastern and southeastern region, and Jeju island (incidence, 12.6 cases /106 people) were major endemic areas. The yearly incidence increased from 36 cases in 2013 to 81 cases in 2015. The main epidemic season was from May to October. The overall case-fatality was 32.6%. The clinical manifestations were similar to known three phases of febrile, multi-organ dysfunctions, and convalescence. Female sex, confusion, the elevation of C-reactive protein, and the prolongation of activated partial thromboplastin time were associated with the death of SFTS patients. Two outbreaks of nosocomial SFTS transmission involving nine healthcare workers during emergency care were observed.

Conclusion: SFTS is a prevalent endemic disease in South Korea still with a high case-fatality rate. Gender, neurologic sign and some laboratory markers were associated with fatal outcome. Nosocomial transmission of SFTS during critical care is of concern.

Seong Jin Choi, MD1, Sang-Won Park, MD, PhD2, In-Gyu Bae, MD3, Sung-Han Kim, MD4, Hee-Chang Jang, MD5, Seong Yeol Ryu, M.D., Ph.D6, Hyun Ah Kim, M.D., Ph.D7, Jeong-Hwan Hwang, MD8, Kyoung-Ho Song, MD9, Ji Whan Bang, MD2, Wan Beom Park, MD10, Eu Suk Kim, MD11, Pyeong-Gyun Choe, MD2, Nam-Joong Kim, MD, PhD12, Myoung-Don Oh, MD, PhD2 and Jongyoun Yi, MD13, (1)Internal Medicine, Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea, Seoul, Korea, The Republic of, (2)Department of Internal Medicine, Seoul National University College of Medicine, Seoul, South Korea, (3)Department of Internal Medicine, Gyeongsang National University Hospital, Jinju, South Korea, (4)Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Korea, The Republic of, (5)Internal Medicine, Chonnam National University Hwasun Hospital, Hwasun, Korea, The Republic of, (6)Infectious Disease, Keimyung University Dongsan Medical Center, Daegu, South Korea, (7)Department of Infectious Disease, Keimyung University Dongsan Medical Center, Daegu, South Korea, (8)Chonbuk National University Medical School, Jeonju-si, South Korea, (9)Seoul National University College of Medicine, Seoul, South Korea, (10)Seoul National University Hospital, Seoul, Korea, The Republic of, (11)Division of Infectious Diseases, Dongguk University Ilsan Hospital, Goyang, South Korea, (12)Seoul Natl. Univ. College of Medicine, Seoul, South Korea, (13)Department of Laboratory Medicine, Department of Laboratory Medicine, Pusan National University School of Medicine, Busan, Republic of Korea, Yangsan-si, Korea, The Republic of

Disclosures:

S. J. Choi, None

S. W. Park, None

I. G. Bae, None

S. H. Kim, None

H. C. Jang, None

S. Y. Ryu, None

H. A. Kim, None

J. H. Hwang, None

K. H. Song, None

J. W. Bang, None

W. B. Park, None

E. S. Kim, None

P. G. Choe, None

N. J. Kim, None

M. D. Oh, None

J. Yi, None

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