Methods: Between 2010 and 2015 - we identified all adult inpatients (age >18) who have a history of recent CDI within 6 months of receiving other antibiotics and identified the subset who received oral vancomycin prophylaxis while on antibiotics. We determined the 6 month relapse rate of this group and compared this relapse rate to all patients at our institution who have a history of recent CDI.
Results: A total of 945 patients met our initial screening criteria but only 90 were determined to have both a history of recent or recurrent CDI and had received prophylaxis with oral vancomycin. Only 6 experienced a recurrent episode of CDI within 6 months accounting for a relapse rate of 6.67%. For our control group - we identified 7445 patients who were diagnosed with Clostridium difficile infection between 2010 and 2015. Out of this group - 1661 patients experienced an episode of recurrent CDI within 6 months. The 6 month relapse rate for our control group was calculated to be 22.2%.
Conclusion: Our findings indicate that oral vancomycin prophylaxis is effective in reducing the relapse rate in patients with a history of recent or recurrent CDI who require treatment with antibiotics as evidenced by the significantly reduced 6 month CDI relapse rate of 6.67% as compared to 22.2% in the control group.