1406. Serologic Investigation among Health Care Workers Contacting MERS Patients during the 2015 Korean MERS Outbreak
Session: Poster Abstract Session: HAI: Outbreaks
Friday, October 28, 2016
Room: Poster Hall



To evaluate the presence of unrecognized MERS-CoV infections among health care workers (HCWs) after the 2015 Korean MERS outbreak, we performed a serologic investigation.


During the outbreak, all HCWs exposed or assigned to MERS patients were quarantined for 14 days and tested screening sputum polymerase chain reaction (PCR) assays thereafter. HCWs with positive PCR results were excluded from the study. We prospectively collected the sera of HCWs exposed or assigned to MERS patients at 6 to 26 weeks post exposure. We primarily used anti-MERS-CoV IgG ELISA, and sera with an optical density (OD) ratio ¡Ã 0.2 were substantiated by immunofluorescence assay (IFA) and plaque reduction neutralization test (PRNT).


Fifty-nine of the 189 HCWs exposed to four highly-infective MERS patients (31.2%) and 130 of 254 HCWs assigned to MERS patient care (51.2%) consented to the study. The median of ELISA OD ratio of exposed HCWs and assigned HCWs were both 0.08 (ranged 0.05-0.26 and 0.22-0.26, respectively), and none of tested sera were positive by IFA and PRNT.


Absence of seroconversion implies that our screening strategy of 14-day symptom monitoring followed by sputum PCR assays appropriately detected MERS-CoV infections and prevented secondary transmissions from HCWs during the MERS outbreak.

Ji-Yeon Kim, Dr.1, Ji Hye Lee, Dr.1, Kyong Ran Peck, Dr.1, Jae-Hoon Ko, Dr.1, Jiyeon Lee, Dr.1, Jin Yang Baek, MA.2, Yae-Jean Kim, MD, PhD1, Eun-Suk Kang, Dr.1, Sun Young Cho, Dr.1, Young Eun Ha, Dr.1, Marcel Müller, Ph.D.3, Christian Drosten, Ph.D.4, Cheol-in Kang, MD1, Doo Ryeon Chung, Dr.1 and Jae-Hoon Song, Dr.1, (1)Samsung Medical Center, Seoul, Korea, The Republic of, (2)Asia Pacific Foundation for Infectious Diseases, Seoul, Korea, The Republic of, (3)University of Bonn Medical Centre, Bonn, Germany, (4)University of Bonn Medical Centre, Bonn, Bonn, Germany


J. Y. Kim, None

J. H. Lee, None

K. R. Peck, None

J. H. Ko, None

J. Lee, None

J. Y. Baek, None

Y. J. Kim, None

E. S. Kang, None

S. Y. Cho, None

Y. E. Ha, None

M. Müller, None

C. Drosten, None

C. I. Kang, None

D. R. Chung, None

J. H. Song, None

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