261. Reduction of Healthcare-Associated Infection Related Events by Replacing Regular Hospital Textiles with Copper Oxide Impregnated Textiles: Crossover, Double-Blind Controlled Study in Chronic, Ventilator-Dependent Patients
Session: Poster Abstract Session: HAI: Environment and Device Cleaning
Thursday, October 27, 2016
Room: Poster Hall
  • Poster Herzog Trial IDWeek finalnumber.pdf (697.3 kB)
  • Background: Healthcare-associated infections (HAI) contribute to morbidity, mortality and healthcare costs. Our objective was to determine if replacing regular textiles with copper oxide biocidal textiles reduces antibiotic treatment initiation (ATI) events, fever days and antibiotic usage among chronic ventilator patients.

    Methods: We conducted a seven months' (February 15-September 15, 2015) double-blind controlled crossover study, divided into 2 intervention periods of 3 months. The periods were separated by a 1-month washout period. All patients in two similar adjacent ventilator-dependent wards in a long-term care hospital were included in the study. During Period I, one ward received copper oxide impregnated linen, hospital patients' clothes and towels, and the other ward received “control" untreated textiles; in Period III the ward that received the treated textiles received the "control" textiles and vice versa. During Period II both wards received usual hospital textiles. The textiles were color coded and all personnel were blinded to which were the treated or control textiles. The infection control measures were the same in both wards. ATI events, fever days, antibiotic treatment days and antibiotics defined daily dose (DDD) were recorded and calculated per 1000 hospitalization days (HD).

    Results: There were 29.19% (P=.002), 55.45% (P<.0001), 22.97% (P<.0001) and 29.22% (P<.001) relative reductions in the ATI events, fever days, antibiotic treatment days and DDD per 1000 HD, respectively, that occurred when using the copper impregnated textiles. In one ward there were 25.63% (P=.093), 49.15% (P<.0001), 17.93% (P=.003) and 18.42% (P<.001) and in the second ward 34.68% (P=.007), 65.08% (P<.0001), 30.30% (P<.0001) and 41.52%, relative reductions in ATI events, fever days, days of antibiotic administration, and DDD per 1000 HD, respectively, when using the treated compared with the untreated textiles.

    Conclusion: The use of copper oxide impregnated biocidal textiles in a long-term care ward of ventilator-dependent patients was associated with a significant reduction of HAI related events and antibiotic administration. Using biocidal textiles may be an important measure aimed at reducing HAI in long-term care medical settings.

    Gadi Borkow, PhD, Cupron Scientific, Gibton, Israel, Esther-Lee Marcus, MD, Chronic Ventilator Dependent Division, Herzog Hospital, Jerusalem, Israel, Hana Yosef, BSN, Infection Control Unit, Herzog Hospital, Jerusalem, Israel, Yehezkel Caine, MD, Herzog Hospital, Jerusalem, Israel, Adi Sasson, MD, Rehabilitation Division, Ministry of Health, Jerusalem, Israel and Allon Moses, MD, Clinical Microbiology and Infectious Diseases, Hadassah Medical Center, Jerusalem, Israel


    G. Borkow, Cupron Inc.: Employee , Salary

    E. L. Marcus, None

    H. Yosef, None

    Y. Caine, None

    A. Sasson, None

    A. Moses, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.