Methods: We obtained demographic and serologic data from serial cross-sectional seroprevalence surveys from convenience samples of children aged 2–11 years recruited in 6 USAPI countries in 1985, 1986, 1991, 1995, 2000, 2005, 2010, 2011, and 2015. Positive hepatitis B surface antigen serologic results were classified as current HBV infections. Vaccination status was determined by vaccination record. Participants who received at least a birth dose of hepatitis B vaccine were considered vaccinated. Descriptive statisticsand a one-way analysis of variance were performed to estimate prevalence of current HBV infection and vaccination coverage for children on the basis of birth year and significant differences in these estimates.
Results: Data were obtained from 4,462 children; 1,323 children (mean age: 7.8 years) born in the 1980s; 362 children (mean age: 4.8 years) born in the 1990s; and 3,142 children (mean age: 6.7 years) born in the 2000s. Of all children, 53.3% were female. Prevalence of current HBV infection significantly decreased (8.4% [1980s]; 2.5% [1990s]; 0.2% [2000s]; P < .0001) as vaccination rates significantly increased (76.4% [1980s]; 87.3% [1990s]; 97.5% [2000s]; P < .0001).
E. H. Teshale, None