159. Surveillance of Influenza among Children Presenting with Febrile Respiratory Symptoms at a Pediatric Clinic in the Guangdong Province of Southern China
Session: Poster Abstract Session: Big Viruses in Little People (Pediatric Viral Diseases)
Thursday, October 27, 2016
Room: Poster Hall
  • SIVFRC_Draft1.pdf (223.3 kB)
  • Background: Children usually have the highest rates of infection during influenza epidemics. Seasonal influenza vaccination is recommended for prevention of infection. We report the result of the impact of influenza vaccination on the rates of influenza infection in children in Southern China.

    Methods: Children presenting to the First Affiliated Hospital with febrile respiratory symptoms were enrolled upon consent of their guardians. Demographics, symptoms, and specific variables of interest were recorded and nasopharyngeal swab was taken. We use descriptive statistics and c2 goodness of fit to report preliminary descriptive results.

    Results: From April 2004 to March 2014, 13,677 children with acute respiratory symptoms were enrolled on the study; 13,207 were included for review, of which 1,537 (11.6%) had a laboratory confirmed diagnosis of influenza (Figure 1). Among them, 1,149 positive cases (74.8%) were Influenza A, with fairly equal distribution of H1 (47.9%) and H3 (52.1%) subtypes. Of the influenza-positive cases, 634 (41%) were female and 903 (59%) were male. Furthermore, 103 (7%) were ≤1 year of age, 544 (35%) were > 1 and ≤ 5 years of age, and 889 (58%) were > 5 and ≤ 18 years of age. Those who were vaccinated had a significantly reduced risk for influenza, RR 0.36 (CI 0.18, 0.70).

    Conclusion: Vaccination was a significant protective factor for children presenting with influenza symptoms. Greater influenza vaccination coverage for children in Southern China is recommended based on this study.


    Miguela Caniza, MD1,2,3, Maysam R. Homsi, MPH1, Li Tang, PhD4, Huachen Maria Zhu, PhD5, Robert G. Webster, PhD1 and Yi Guan, PhD5, (1)Infectious Diseases, St. Jude Children's Research Hospital, Memphis, TN, (2)Global Pediatric Medicine, St. Jude Children's Research Hospital, Memphis, TN, (3)International Outreach Program, St. Jude Children's Research Hospital, Memphis, TN, (4)Biostatistics, St. Jude Children's Research Hospital, Memphis, TN, (5)Shantou University Medical College, Shantou, China


    M. Caniza, None

    M. R. Homsi, None

    L. Tang, None

    H. M. Zhu, None

    R. G. Webster, None

    Y. Guan, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.