568. Host Factors Associated with Poor Respiratory Health-Related Quality of Life in Pulmonary Tuberculosis
Session: Poster Abstract Session: Tuberculosis Treatment and Outcome
Thursday, October 27, 2016
Room: Poster Hall
  • ID Week 2016 Poster Lung Health Substudy.pdf (611.5 kB)
  • Background: Despite treatment, up to 70% of pulmonary tuberculosis (PTB) patients have poor Health-related Quality of Life (HrQOL) associated with chronic lung injury. Early identification of these patients may improve clinical care, but data are lacking.

    Methods: New adult drug-susceptible PTB cases presenting to the DOTS clinics in Pune and Chennai, India, since October 2014 were enrolled and evaluated at anti-tuberculosis treatment (ATT) initiation, two months of ATT and ATT completion. Those with a history of chronic lung diseases were excluded. HrQOL was assessed by the Saint Georges Respiratory Questionnaire (SGRQ); a multi-domain questionnaire validated for respiratory diseases. Higher SGRQ scores indicate worse respiratory HrQOL; and correlate with airflow limitation, functional impairment and hypoxemia. The minimum clinically important difference in SGRQ scores has been determined to be four points. Associations between host factors during early ATT and SGRQ scores at ATT completion were measured using random effects regression models.

    Results: 147 participants completed ATT by April 2016 and had SGRQ scores available for analysis. Median age was 39 years (IQR 27-48), 66% were males, 11% were HIV coinfected, 21% had diabetes mellitus and 37% smoked. Mean (SD) total SGRQ scores at ATT initiation, two months of ATT and ATT completion were 48 (21), 27 (20) and 15 (14) respectively (p<0.001 for difference in means). Participants aged 50 years and older had at least a four point higher total SGRQ score at ATT completion than their younger counterparts (p=0.01)Random effects regression models adjusted for age, sex, smoking and total SGRQ scores at ATT initiation identified older age (aOR=1.63 per 10-year increment; p=0.02) and higher total SGRQ scores at two months of ATT (aOR=1.13 per 4-point increment; p=0.04) as independent predictors of having total SGRQ scores in the highest quartile despite ATT completion.

    Conclusion: Older patients, and those with higher SGRQ scores at two months of ATT, had worse HrQOL despite ATT completion and may benefit from interventions to limit chronic pulmonary sequelae of TB. Studies exploring the underlying mechanisms of lung injury, especially during the first two months of ATT, may inform adjuvant therapies for reducing pulmonary morbidity.

    Akshay Gupte, MBBS, MSPH1, Sushant Meshram, MD2, Sriram Selvaraju, MBBS, MPH3, Nikhil Gupte, PhD4, Shri Vijay Bala Yogendra Shivakumar, MD5, Mandar Paradkar, MD, MPH2, Rewa Kohli, PhD2, Kannan Thiruvengadam, MSc, Mphil3, Nishi Suryavanshi, PhD2, Padmapriyadarasini Chandrasekaran, MD6, Vidya Mave, MD, MPH2, Soumya Swaminathan, MD7, Sundeep Salvi, MD, PhD8, William Checkley, MD, PhD9, Jonathan Golub, MPH, PhD9 and Amita Gupta, MD, MHS9, (1)Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, (2)Byramjee Jeejeebhoy Government Medical College, Pune, India, (3)National Institute for Research in Tuberculosis, Chennai, India, (4)Johns Hopkins University School of Medicine, Pune, MD, (5)Johns Hopkins University-India office, Pune, India, (6)Clinical Research, National Institute for Research in Tuberculosis, Chennai, India, (7)Indian Council of Medical Research, New Delhi, India, (8)Chest Research Foundation, Pune, India, (9)Johns Hopkins University School of Medicine, Baltimore, MD


    A. Gupte, None

    S. Meshram, None

    S. Selvaraju, None

    N. Gupte, None

    S. V. B. Y. Shivakumar, None

    M. Paradkar, None

    R. Kohli, None

    K. Thiruvengadam, None

    N. Suryavanshi, None

    P. Chandrasekaran, None

    V. Mave, None

    S. Swaminathan, None

    S. Salvi, None

    W. Checkley, None

    J. Golub, None

    A. Gupta, None

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