156. Laboratory-Confirmed Human Coronavirus (HCoV) Infections among Children: Does Type Matter?
Session: Poster Abstract Session: Big Viruses in Little People (Pediatric Viral Diseases)
Thursday, October 27, 2016
Room: Poster Hall
  • IDSA Poster (HCoV) Final-- IDSA 2016-VII.pdf (1.1 MB)
  • Background: Human Coronaviruses (HCoV) cause illness ranging from the common cold to life-threatening pneumonia. However, the reported clinical epidemiology and burden of HCoV infection is confounded by frequent co-detection with other respiratory viruses. While different types of HCoV can be detected by laboratory testing, few data exist describing single HCoV infection by type in children.

    Methods:  We conducted a retrospective cohort study of children <18 years with single HCoV detection from 12/2012-2/2016 at Primary Children’s Hospital, Salt Lake City, UT. Demographic, clinical, and financial data of children with moderate to severe single HCoV infection (hospitalized ≥24 hours) were evaluated by HCoV type (HKU1, OC43, 229E, NL63). Testing was performed using the FilmArray® Respiratory panel, BioFire Diagnostics, LLC, Salt Lake City, UT.

    Results:  Over the study period, a respiratory virus was detected in 11,714 of 19,150 (61%) children undergoing respiratory viral testing at PCH, with HCoV accounting for 1267 (11%) of detected viruses.  Of these, single HCoV infection occurred in 534 children (42% of HCoV detections) comprising the study cohort; 207 (39%) were hospitalized ≥24 hours. The overall median age was 14 months (interquartile range [IQR] 3-46). A chronic medical condition (CMC) was present in 62 (30%) children, with 69 (33%) requiring intensive care unit (ICU) admission and 28 (14%) requiring mechanical ventilation. The median length of stay (LOS) was 2.5 days (IQR 1.5-4.7) and hospital cost was $6,502 (IQR: $3,708-$14,280) (Table). CMCs were noted more frequently in children with HCoV NL63 (32 (43%)) compared to HCoV OC43 (14 (18%)) (p=0.008). ICU admission, mechanical ventilation, median hospital LOS and cost comparable among the different HCoV types. Death from HCoV (3 (1%)) was rare among children with moderate to severe single HCoV infection.

    Conclusion:  HCoV infection is a common cause of respiratory illness among children.  Among children with single HCoV detection, 35% to 42% of each type required hospitalization for ≥24 hours.  Outcomes in children with HCoV infection alone were comparable to each other, and associated with a substantial clinical and economic burden for all of the HCoV types.














    Susan K. Sanderson, DNP1, Chris Stockmann, PhD, MSc1, Andrew Pavia, MD, FIDSA, FSHEA, FPIDS1, Carrie L. Byington, MD, FIDSA2, Anne J. Blaschke, MD, PhD, FIDSA, FPIDS1, Emily Thorell, MD, MSCI1, Adam L. Hersh, MD, PhD3, E. Kent Korgenski, MS4, Judy a. Daly, PhD5 and Krow Ampofo, MD, FIDSA, FPIDS1, (1)Department of Pediatrics, Division of Pediatric Infectious Diseases, University of Utah School of Medicine, Salt Lake City, UT, (2)Pediatrics, University of Utah, Salt Lake City, UT, (3)University of Utah School of Medicine, Salt Lake City, UT, (4)Department of Pediatrics, Pediatric Clinical Program, University of Utah School of Medicine and Intermountain Healthcare, Salt Lake City, UT, (5)Clinical Microbiology, Primary Children's Hospital, Salt Lake City, UT


    S. K. Sanderson, None

    C. Stockmann, None

    A. Pavia, None

    C. L. Byington, None

    A. J. Blaschke, BioFire Diagnostics, LLC: Advisor regarding risks associated with FDA-cleared products and Collaborator , Consulting fee and Licensing agreement or royalty

    E. Thorell, None

    A. L. Hersh, Merck: Grant Investigator , Research grant

    E. K. Korgenski, None

    J. A. Daly, None

    K. Ampofo, None

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.