2033. Antimicrobial Resistance among Campylobacter Isolated from Blood in the United States, 2005–2014
Session: Poster Abstract Session: Antimicrobial Resistant Infections: Treatment
Saturday, October 29, 2016
Room: Poster Hall
Background: Campylobacter causes an estimated 1.3 million illnesses in the United States each year. C. jejuni and C. coli cause most human illness. Most infections result in self-limited gastroenteritis but antimicrobial treatment is critical for bloodstream infections. Macrolides (e.g., erythromycin) are agents of choice. Ciprofloxacin is recommended with caution, due to increasing resistance. We compared patient characteristics and antimicrobial resistance of Campylobacter isolates from blood and stool.

Methods: CDC’s National Antimicrobial Resistance Monitoring System (NARMS) receives Campylobacter isolates from 10 sites participating in the Foodborne Diseases Active Surveillance Network (FoodNet). We linked NARMS isolate data to FoodNet patient data for outcome and recent international travel. We categorized isolates with resistant or intermediate MICs defined by the Clinical and Laboratory Standards Institute as resistant to erythromycin (ERY-R) and ciprofloxacin (CIP-R). We used Fisher’s exact test to compare characteristics of patients with blood and stool isolates.

Results: During 2005–2014, we tested 12,200 Campylobacter blood and stool isolates; 115 (0.9%) were from blood, of which 68% were C. jejuni, 14% C. fetus, 10% C. coli, 6% C. upsaliensis, and 2% other species. Bacteremia was associated with non-jejuni/coli species, age ≥65 years, hospitalization, and death (all p<0.01). Travel was less likely among patients with blood isolates (p<0.01). Among blood isolates, 2% were ERY-R and 21% were CIP-R; this did not significantly differ from resistance among stool isolates (2% ERY-R, 23% CIP-R). Comparing CIP-R to susceptible isolates from blood, the proportions of patients age ≥65 years, hospitalized, or reporting travel did not significantly differ.

Conclusion: Blood isolation of Campylobacter was rare; however, it was more likely in elderly patients and for non-jejuni/coli species. Bloodstream infections were associated with adverse outcome and nearly one quarter of bloodstream infections were ciprofloxacin-resistant. Clinicians should consider the possibility of resistance when considering fluoroquinolones for treatment of invasive Campylobacter infection.

Jared Reynolds, MPH1, Christy Bennett, BS2, Jennifer Huang, MPH1 and Felicita Medalla, MD1, (1)Enteric Diseases Epidemiology Branch, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention, Atlanta, GA, (2)Enteric Diseases Laboratory Branch, Division of Foodborne, Waterborne and Environmental Diseases, Centers for Disease Control and Prevention/IHRC, Inc., Atlanta, GA

Disclosures:

J. Reynolds, None

C. Bennett, None

J. Huang, None

F. Medalla, None

Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.