646. Influenza and other respiratory viral infections among schoolchildren in Pittsburgh, Pennsylvania, USA
Session: Poster Abstract Session: Oh, Those Pesky Viruses!
Thursday, October 27, 2016
Room: Poster Hall
Background: Information on etiology and age-specific burden of respiratory viral infections among school-aged children and the interaction of these infections with influenza remains limited.

Methods: We conducted a cohort study to determine the etiology of ILI (influenza like illness) among 2,519 K-12 students during the 2012-13 influenza season. We determined, by parent interview, the reasons of students’ absences, and obtained nasal swabs from students with ILI-related absences. Generalized, linear, mixed-effect regressions were performed to determine the associations of outcomes, including ILI and laboratory-confirmed respiratory virus infections with age and other covariates.

Results: Overall, 552 ILI-related absences occurred; swabs were obtained from 464 (84%) of these. One or more respiratory viruses were found in 358 (77%) samples. Influenza was found in 195 (42%) samples. Influenza B accounted for 135 (69%) of laboratory-confirmed influenza infections. Rates of influenza B were significantly higher in grades 1 (10.1% 95% CI 6.8%, 14.4%), 2 (9.7% (95% CI 6.6%,13.6%), 3 (9.6% 95% CI 6.5%, 13.5%), and 4 (10.2% 95% CI 7.0%, 14.2%) than in kindergarteners (3.2% 95% CI 1.5%, 6.0%), The likelihood of having influenza B was also lower among children in half-day kindergarten programs compared to children in full-day kindergarten programs (OR = 0.83; 95% CI 0.59 - 0.93).

Conclusion: Acquisition of influenza and other respiratory pathogens in K-12 schools may be reduced by a truncated school day. Further studies are needed in order to determine if half-day at school instruction would have an effect on controlling influenza and other ILI-related viral respiratory disease outbreaks in school.

Shanta Zimmer, MD1, Jonathan Read, PhD2, Charles Vukotich Jr., MS3, Mary Lou Schweizer, MS4, David Galloway, MS1, Eva Noble, MPH5, Jeanette Rainey, PhD6, Hongjiang Gao, PhD7, Amra Uzicanin, MD, MPH7 and Derek Cummings, PhD8, (1)University of Pittsburgh, Pittsburgh, PA, (2)Institute of Infection and Global Health, University of Liverpool, Neston, United Kingdom, (3)Medicine, University of Pittsburgh School of Medicine, Pittsburgh, PA, (4)University of PIttsburgh, Pittsburgh, PA, (5)Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, (6)Centers for Disease Control and Prevention, Atlanta, GA, (7)CDC, Atlanta, GA, (8)Biology, University of Florida, Gainesville, FL

Disclosures:

S. Zimmer, None

J. Read, None

C. Vukotich Jr., None

M. L. Schweizer, None

D. Galloway, None

E. Noble, None

J. Rainey, None

H. Gao, None

A. Uzicanin, None

D. Cummings, None

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