408. Risk Factors for the Development of Implanted Chest Port Related Infections in Oncology Patients
Session: Poster Abstract Session: HAI: Preventing Device-Associated Infections
Thursday, October 27, 2016
Room: Poster Hall
Background:

Central line associated infections pose a significant risk of morbidity and mortality, particularly in oncology patients. Risk factors predisposing these patients for development of port-a-catheter related infections, such as port-site cellulitis and blood stream infections (BSI), are disputed in current literature. The aims of this investigation were to assess factors which identify oncology patients at increased risk of developing port-a-catheter related infections and determine if any organisms are frequently involved.

Methods:

Records of 1295 patients that underwent port removal from January 1, 2008 to December 31, 2015 were reviewed. Inclusion criteria required diagnosis of malignancy and positive blood or port site cultures collected prior to port removal. Records of 129 total patients met the criteria. Rates of neutropenia and organisms recovered from culture were tabulated. Patients were categorized by solid organ or hematogenous malignancy. Chi-square analysis was performed to determine statistical significance among the rates of port related infection, neutropenia, and organisms recovered from culture between the two groups.

Results:

Of the 1235 oncology patients undergoing port-a-catheter removal, BSI and port-site cellulitis had developed in 110 and 19 patients, respectively. 80 of 998 patients (8%) with solid organ malignancies versus 49 of 237 (20.7%) with hematogenous malignancies had developed port site cellulitis or BSIs (p <0.01). While only 53 oncology patients were neutropenic at the time of port removal, 43 had concomitant BSIs (p <0.01). Additionally, the frequencies of gram positive bacteria, gram negative bacteria, and fungal isolates recovered from cultures were similar between the two patient populations.

Conclusion:

Prior investigations have identified that patients with neutropenia or underlying hematologic malignancies are at increased of BSI. Although only those patients with implantable port-a-catheters were examined, the results of this study reinforce those observations. Surprisingly, organisms recovered from oncology patients with BSIs were not significantly different between those with solid organ and hematologic malignancies, and Staphylococcus aureus was the most commonly isolated organism overall.

Chandresh Shah, MD1, Ashley Lee, BS2, John Harris Jr., MD1, Tomas Mujo, DO1, Melissa Potts, MD1 and Douglas Coldwell, MD, PhD1, (1)Radiology, University of Louisville, Louisville, KY, (2)University of Louisville School of Medicine, Louisville, KY

Disclosures:

C. Shah, None

A. Lee, None

J. Harris Jr., None

T. Mujo, None

M. Potts, None

D. Coldwell, None

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