791. Incidence of acute otitis media in the vaccines era against pneumococcus in a city of the Colombia Caribbean Coast: a cohort study.
Session: Poster Abstract Session: Vaccines: Pneumococcal
Thursday, October 27, 2016
Room: Poster Hall
Posters
  • IDWeek. Poster incidencia2.pdf (814.1 kB)
  • Background: Acute otitis media (AOM) is one of the main bacterial infection in children. Pneumococcus and Nontypeable Haemophilus influenzae (NTHi) are responsible for up to 80% of cases. In Colombia the pneumococcal conjugate vaccine 10 serotype was included in the immunization program since 2011.

    Aim: to determine the incidence of AOM in a cohort of newborn in Cartagena, Colombia.

    Methods: a prospective cohort study was performed in a sample of newborn in Cartagena’s Maternity Clinic from December 2013 to August 2015 with a follow-up period of 15 months. For the caregivers were surveyed at the time of inclusion and every three months to identify AOM cases. Otolaryngologyst evaluated the patients by otoneumatoscopia and according to the American Academy of Pediatrics (AAP) criteria for AOM was considered sampling (timpanoscentesis by CDT® Speculum). Isolates of Haemophilus influenzae and pneumococcal were sent to the National Health Institute (NHI) for serotyping.

    Results: from a population of 1560 newborn we enrolled a total of 876 newborn. The percentage of loss during the 5 followed up were 0%, 23%, 28.6%, 5.5% and 21.5%.  53.1% were male, 9 out of 10 households had a very low socioeconomic status. 23.5% of infants were exposed to cigarette smoke and 44.4% biomass at birth. 67.9% had siblings under 10 years, where 11.1% had AOM. The median of exclusive breastfeeding was 3 months [IQR 2.0; 5.0], time of weaning was 5.0 months [IQR 4.0; 6.0]. The infants had on timely vaccination schedule at the first, second and fourth of follow up were 61.8%, 59.4% and 58.7%, respectively. 44 cases with AOM were diagnosed. The incidence rate was 29.4% per 1,000 infants episodes year. Secretion cultivation was performed in 44.5% of cases, Hi was isolated in 20% (4/20) all reported by NHI as nontypeable negative B-lactamase. Pneumococcus was isolated in 15% (3/20), only one was serotyping as 6C. S. pyogenes and S. aureus were isolated each in 10% (2/20) of cases.

    Conclusion: This is the first cohort study about incidence of AOM in the post PCV-10 era. The incidence is lower than anothers authors (D. Teele, Prymula, Eskola, Liese), however it is compatible with the findings of other authors (Tregnaghi, Bardach) in Latin America, where as the present study, the diagnosis was by otolaryngologist.

    Wilfrido Coronell-Rodríguez, PhD (C) Tropical Medicine1, Cindy Arteta-Acosta, Student Master of Epidemiology1, Steven Osorio-Anaya, Resident of Otolaryngology2, Fernando De La Hoz, PhD3 and Nelson Alvis-Guzman, PhD2, (1)Faculty of Medicine, Universidad de Cartagena, Cartagena, Colombia, (2)Universidad de Cartagena, Cartagena, Colombia, (3)Universidad Nacional, Bogota, Colombia

    Disclosures:

    W. Coronell-Rodríguez, COLCIENCIAS: Administrative Department of Science, Technology and Innovation in Colombia , Research grant and Research support

    C. Arteta-Acosta, COLCIENCIAS: Administrative Department of Science, Technology and Innovation in Colombia , Research grant and Research support

    S. Osorio-Anaya, COLCIENCIAS: Administrative Department of Science, Technology and Innovation in Colombia , Research grant and Research support

    F. De La Hoz, COLCIENCIAS: Administrative Department of Science, Technology and Innovation in Colombia , Research grant and Research support

    N. Alvis-Guzman, COLCIENCIAS: Administrative Department of Science, Technology and Innovation in Colombia , Research grant and Research support

    << Previous Abstract | Next Abstract

    Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.