LB-2. MORTALITY IN NEWBORNS WITH MICROCEPHALY DUE TO MATERNAL ZIKA VIRUS INFECTION IN RIO GRANDE DO NORTE STATE – NORTHEAST BRAZIL: A CROSS-SECTIONAL ANALYSIS
Session: Oral Abstract Session: Late Breaker Oral Abstracts
Saturday, October 29, 2016: 10:40 AM
Room: 283-285
Background: An increase in the number of newborns with microcephaly (MCP) was noted in 2015 in regions of Northeast Brazil. Many studies have been published showing causal relationship between ZIKV congenital infection and microcephaly in newborn. This study aims to assess the mortality in newborns with microcephaly due to ZIKV congenital infection from April 2015 to June 2016 in the Rio Grande do Norte State (RN), a Brazilian Northeast State that has an estimated population of 3,400,000 inhabitants. Methods: Data were obtained through epidemiological bulletin from Brazilian Ministry of Health (BMH) during the period from April 2015 to June 30, 2016. Results: During the study period, there were 435 cases of MCP notified in RN, of which 113 were already confirmed and 256 remain under investigation. Of the total confirmed cases, 15.9% (18/113) died after birth or during pregnancy. The BMH has reported that 67% (12/18) of confirmed deaths had ZIKV infection during pregnancy as the causal agent: 7 had a CT scan showing abnormalities of the central nervous system (presence of typical and indicative alterations of congenital ZIKV infection) and 5 were confirmed by RT-PCR and/or IgM/IgG antibodies against ZIKV. The remaining 6 cases of deaths remain under investigation. Conclusions: Our findings show a high rate of mortality (67%) in newborns with MCP due to ZIKV congenital infection. An increase in the prevalence of microcephaly was seen especially from September 2015, with the highest rate in November 2015 (22.3 cases per 1,000 live births). Before this ZIKV outbreak, the records in RN between 2010 and 2014 was around 1,8 cases/year. Despite the growing number of cases of microcephaly caused by ZIKV, it is difficult to assess the real increase in the prevalence of MCP in RN. It is related to the underreporting cases and lack of resources for diagnostic tests (laboratory and imaging) and research development. Because the ZIKV outbreak is still not under control, it might increase the infant mortality rate in Brazil. The data presented suggests that the current ZIKV outbreak might decrease the Brazilian’s level of health. It highlights the need for developing public health programs to control the ZIKA outbreak. The impact of MCP associated to ZIKV are still to be determined.
Nilson Nogueira Mendes Neto, MS, Medical School, Universidade Potiguar - Laureate International Universities, Natal - RN, Brazil, Jessika Thais Da Silva Maia, MS, Universidade Potiguar, Natal - RN, Brazil, Daniel Duarte Rolim, MS, FCM, Campina Grande - PB, Brazil, S. Jayne Alves Vidal, Nurse, SESAP, Natal, Brazil, Tatyana Vidal Mendes, Nurse, Faculdade Santa Maria, cajazeiras-PB, Brazil, Marcelo Rodrigues Zacarkim, MD, Harvard Medical School, Boston, MA, Igor Thiago Queiroz, MD, PhD, Universidade Potiguar, natal, Brazil, David Pierre, MD, Brazilian Navy, Natal - RN, Brazil, Luiz Alberto Carneiro Marinho, M.D., PhD, Hospital Giselda Trigueiro, Natal - RN, Brazil and Thiago Gomes Da Trindade, M.D., PhD, Universidade Federal do Rio Grande do Norte, Natal, Brazil

Disclosures:

N. Nogueira Mendes Neto, None

J. Thais Da Silva Maia, None

D. Duarte Rolim, None

S. J. Alves Vidal, None

T. Vidal Mendes, None

M. Rodrigues Zacarkim, None

I. Thiago Queiroz, None

D. Pierre, None

L. A. Carneiro Marinho, None

T. Gomes Da Trindade, None

Findings in the abstracts are embargoed until 12:01 a.m. CDT, Wednesday Oct. 26th with the exception of research findings presented at the IDWeek press conferences.