600. Immunological Changes In HIV Infected Patients After Supervised Exercise Thet, A; Figueroa, N; Rodrigues, J; Singleton, R; Sivapalan, V; Mannheimer, S
Session: Poster Abstract Session: HIV: Pathogenesis and Inflammation
Thursday, October 5, 2017
Room: Poster Hall CD
Background:

Despite the significant positive effect of HAART therapy on physical and psychosocial well-being of people living with HIV, several studies have shown acute improvement in the immunologic function in supervised exercise programs. Our study investigated the effect of a 24 week mild to moderate aerobic exercise training on immunologic parameters, CD4, CD4%, CD8, CD8%, CD4/CD8, WBC, Lymphocytes during 6 months of exercise and 6 months to 1 year post-study period.

Methods:

Overweight and obese (mean BMI 32 +/– 6.5) adults recruited in an inner city HIV clinic participated in instructor-led group exercise for 60 minutes 2-3 times a week for 24 weeks at low to moderate intensity. Participants received routine standard clinical care. Inclusion criteria are BMI >25 kg/m2 with type 2 diabetes (36 %), hypertension (61 %), hyperlipidemia (47%) and/or depression (36%). Pregnant women, patients not medically stable for exercise or active psychosis were excluded.  Paired longitudinal data analysis was used in data analysis. The exercise group and control group were compared separately at baseline, 6 months and 1 year.

Results:

Participants ( N=36 ) were 56% black, 14% Hispanic and 30% African descent; 56% females, 44% males; median age 53.5+/- 9.5 years, median CD4% 29.8 (1.56) at pre-exercise; 67% were HIV virally suppressed. 97% were on long term HAART, 50% on PI based HAART. Participant median CD4% significantly rebounded 6 months post exercise. CD8 dropped significantly from baseline to 1 year post exercise. CD8% dropped significantly from 6 months to 1 year post exercise and the baseline to 1 year post exercise. CD4/CD8 ratio significantly improved from 6 months to 1 year, and also from baseline to 1 year.

Conclusion:

Supervised exercise improved CD4% from 6th month to one year and CD4/CD8 improved from baseline to 1 year post exercise. However CD 8 % significantly dropped in intervention group compared to consistent rise in control group from the baseline to 1 year. This findings could be explained by the role of adipocytes, physical stress from exercise and the role of inflammatory markers on the immune system.

Andrea Thet, MD, Infectious Disease, Harlem Hospital, NY, NY and Figueroa, N; Rodrigues, J; Singleton, R; Sivapalan, V; Mannheimer, S

Disclosures:

A. Thet, None

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