1321. A Successful Strategy to Reduce Hospital-Onset Clostridium difficile
Session: Poster Abstract Session: HAI: C. difficile Risk Assessment and Prevention
Friday, October 6, 2017
Room: Poster Hall CD
  • Poster 1321 - Cambridge Proof ID Week 2017.pdf (1.1 MB)
  • Background: Our goal was to reduce the rate of hospital-onset (HO) C. difficile  (CD) by prompt testing in patients with diarrhea on hospital day (HD) 1-3 using a nurse-driven testing protocol (NTP) with PCR and improve identification of disease after HD 3 using a combined toxin/antigen assay (TAA).

    Methods: An automated best practice advisory/NTP was developed in Epic, triggered by documentation of diarrhea during HD 1-3, to facilitate prompt stool collection, testing and initiation of contact precautions. Education was provided. The NTP was fully implemented at 2 community-teaching hospitals mid-February 2016. The TAA was adopted 7/27/16 for testing after HD 3.

    Results: In 2016, the standardized infection ratio (SIR) at Cambridge and Everett was 0.43 (p=0.009) and 0.5 (p=0.017), respectively, reflecting a 48-61% decrease from 2015. There was a 14-28% improvement in identifying cases as community-onset. The TAA led to a further decline in HO-CD by 10-61%. Refer to the graph for quarterly SIRs before and after implementation. Despite a 26% increase in testing volume, costs are less with the current strategy.

    Conclusion: Prompt identification of CD improves care and prevents inflation of HO-CD. This strategy has enhanced our efforts to reduce our SIR (observed/expected cases) and resulted in a substantial incentive payment for CHA.  


    Lou Ann Bruno-Murtha, DO, Harvard Medical School, Cambridge, MA; Medicine, Cambridge Health Alliance, Cambridge, MA, Rebecca Osgood, MD, Pathology, Cambridge Health Alliance, Cambridge, MA, Casey Alexandre, RN, Nursing, Cambridge Health Alliance, Cambridge, MA and Rumel Mahmood, MSc, Quality, Cambridge Health Alliance, Cambridge, MA


    L. A. Bruno-Murtha, None

    R. Osgood, None

    C. Alexandre, None

    R. Mahmood, None

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