653. Use of single-dose azithromycin to control a community outbreak of emm26.3 group A Streptococcus invasive disease— Alaska, 2017
Session: Poster Abstract Session: Outbreaks and Public Health Across the Globe
Thursday, October 5, 2017
Room: Poster Hall CD
Posters
  • Mosites GAS surveillance_outbreak IDSA_10-2-17.pdf (373.4 kB)
  • Background: In July 2016, invasive infections caused by a rare subtype of group A Streptococcus (iGAS; subtype emm26.3) were detected among the estimated 700-1000 homeless persons in Anchorage, Alaska. An increase in case numbers of emm26.3 iGAS was detected in October, including one death. We implemented a mass antibiotic intervention at homeless service facilities in Anchorage to prevent further cases of emm26.3 iGAS.

    Methods: We defined cases as the isolation of emm26.3 GAS from a normally sterile body site, or nonsterile sites in the case of necrotizing fasciitis or toxic shock syndrome. We identified cases through routine laboratory-based surveillance and conducted antimicrobial susceptibility testing on all invasive isolates. From February 13–18, 2017, we evaluated persons accessing homeless services at six facilities in Anchorage and offered a single oral dose of 1 gram of azithromycin for iGAS prophylaxis. We concurrently collected oropharyngeal (OP) and wound swab specimens on a subset of participants. The swab collection was repeated at the same locations 4 weeks after the intervention. Swabs were cultured for GAS and emm-typed.

    Results: From October 1, 2016 through February 18, 2017, we detected 31 cases among homeless persons. All emm26.3 iGAS isolates were erythromycin susceptible. We evaluated 484 persons at homeless services facilities and provided azithromycin to 394 (81%). Of 289 swab participants, 9 (3.1%) had baseline emm26.3 OP colonization. Of participants with wounds, 3/71 (4.2%) had emm26.3 wound colonization. At follow-up, 3/298 (1.0%) participants had emm26.3 OP colonization and 1/63 (1.6%) had emm26.3 wound colonization (P-value for change in any colonization=0.05). Colonization by other emm-types, primarily erythromycin non-susceptible emm11, was 5.1% at baseline and 5.0% at follow-up. In the 6 weeks post-intervention, we detected 1 case among homeless persons (0.2 cases/week post- vs. 1.6 cases/week pre-intervention, P=0.01 for change).

    Conclusion: We reached a substantial proportion of the Anchorage homeless population with an antibiotic intervention to prevent iGAS. While possible that the outbreak was waning, the intervention was temporally associated with reduced case counts and colonization prevalence.

    Emily Mosites, PhD MPH1, Anna Frick, MPH2, Prabhu Gounder, MD MPH1, Louisa Castrodale, DVM2, Karen Rudolph, PhD1, Debby Hurlburt, RN BSN1, Tammy Zulz, MPH1, Tolulope Adebanjo, MD3, Jennifer Onukwube, MPH3, Chris Van Beneden, MD, MPH4, Joseph Mclaughlin, MD2, Thomas Hennessy, MD, MPH1 and Michael Bruce, MD, MPH1, (1)Arctic Investigations Program, Centers for Disease Control and Prevention, Anchorage, AK, (2)Section of Epidemiology, Alaska Division of Public Health, Anchorage, AK, (3)National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, (4)Respiratory Diseases Branch, Centers for Disease Control and Prevention, Atlanta, GA

    Disclosures:

    E. Mosites, None

    A. Frick, None

    P. Gounder, None

    L. Castrodale, None

    K. Rudolph, None

    D. Hurlburt, None

    T. Zulz, None

    T. Adebanjo, None

    J. Onukwube, None

    C. Van Beneden, None

    J. Mclaughlin, None

    T. Hennessy, None

    M. Bruce, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.