2344. Clinical and Epidemiological Profile of the Chikungunya and Zika Outbreak in Neonates 2014-2016, Cartagena-Colombia
Session: Poster Abstract Session: Pediatric Virology
Saturday, October 7, 2017
Room: Poster Hall CD
Posters
  • 30 Sep-2017 Poster Zika and ChikV-Final.pdf (1.1 MB)
  • Background: African researchers noted that aedes-transmitted Zika epizootics tended to follow aedes-transmitted Chikungunya virus (CHIKV) epidemics. In 2013 CHIKV spread pandemically from Africa-Asia, and Zika followed (1). Cartagena has been affected since 2014 by arboviruses with the most severe clinical forms in fetus, neonates and pregnant (1-4). Aim: To describe clinical, epidemiological profile of CHIKV and ZIKA neonatal (CHIK-neonatal, ZIKA-neonatal) in Cartagena-Colombia, between September-2014/June-2016.

    Methods: Case Series, we incluided neonates from 3-NICs were classified as suspected/confirmed cases of CHIK-neonatal and ZIKA-neonatal by RT-PCR.

    Results: Between September-December 2014, 12 newborns with mean gestational age 38 weeks±1.2SD were included as CHIK-neonatal cases, 66.8% (8/12) of mothers presented symptoms confirmed by CHIKV four-days before or two-days after the delivery. Neonates had symptoms average 7.7days±6.9SD, median 5[2,7]. Sign-Symptoms: 100% irritability-pain, 83.3% fever, 66.6% exfoliative dermatitis, 58.3% rash, vomiting, abdominal distension and joint edema 16.6% each, 8.3% meningeal syndrome. All RT-PCR were positive for CHIKV and leukopenia with lymphopenia. Between December-2015 to June-2016, 23 newborns with malformations and/or epidemiological data from mother with Zika-infection confirmed by RT-PCR, were included. 85.7% were controlled pregnancy, Median-maternal age 23years [17.0-30.0], 42.8% of mothers had Zika symptoms in first trimester, median 10weeks [10.0-30.0]. 42.9% had vaginal delivery, Median gestational age 37.2weeks [37.0-39.3]. Median Weight 2840grams [2490-3420], Size 48cm [45-51], 57.1% female. 85.7% of newborn had microcephaly, 28.6% xeroderma-desquamation, arthrogryposis, perinatal asphyxia each, 28.6% myelomeningocele, ventriculomegaly, microlisencephaly, calcifications and cerebellar hypoplasia, 14.3% ocular alterations. Normal hemograms, positive Zika-RT-PCR, negative Dengue, CHIKV and negative serology for TORCHS.

    Conclusion: CHIK-neonatal and ZIKA-neonatal are an increasing possibility and must be considered in the approach of TORCHS complex (5). The maternal epidemiological background is fundamental in the diagnostic in endemic areas.

    Cindy Arteta-Acosta, Master of Epidemiology1,2 and Wilfrido Coronell-Rodríguez, PhD Tropical Medicine, Infectious disease Pediatrician1, (1)Faculty of Medicine, Universidad de Cartagena, Cartagena, Colombia, (2)Medicine, Universidad del Norte, Barranquilla, Colombia

    Disclosures:

    C. Arteta-Acosta, None

    W. Coronell-Rodríguez, None

    See more of: Pediatric Virology
    See more of: Poster Abstract Session

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.