1033. Evaluation of serum TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever
Session: Poster Abstract Session: Adult Viral Infection
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • Evaluation of serum TNF-alpha, IL-6, IL-10, and IFN-gamma levels in patients with Crimean-Congo hemorrhagic fever.pdf (242.5 kB)
  • Background: Crimean–Congo hemorrhagic fever (CCHF) is a potentially fatal disease caused by a tick-borne virus from the Bunyaviridae family. Cytokines plays an important role in the pathogenesis of viral, bacterial, and immunologic diseases. This study aimed to investigate the role of TNF-alpha, IL-6, IL-10, and IFN-gamma levels in the severity of infection and clinical outcome of patients with CCHF.

    Methods: Patients with confirmed CCHF were divided into two groups (severe cases: Patients who exhibited hemorrhage during their hospital stay, and mild/moderate cases: Patients who displayed no hemorrhage during their hospital stay). Demographic characteristics, laboratory tests on admission of all patients with CCHF were investigated, and serum TNF-alpha, IL-6, IL-10, and IFN-gamma levels were measured.

    Results: A total of 154 patients with confirmed CCHF were investigated. Forty-six (29,9%) of these patients were in the severe group. In patients with severe CCHF, significantly higher serum levels of TNF-alpha (68.2±23.5; P=0.008) and IL-6 (73.1±41.6; P=0.003) were detected, compared with cytokine levels in patients who mild/moderate CCHF (Table 1). No differences in serum IL-10 and IFN-gamma levels between patients who severe CCHF and those who mild/moderate CCHF were detected (P>0.05).

    Table 1: Cytokine levels, demographic and laboratory characteristics in patients with severe and mild/moderate cases with CCHF

    Features

    Severe cases

    n=46

    Mild/moderate cases

    n=108

    P-value

    Age

    50,6±20,3

    49,8±21,0

    0,682

    Female gender, n (%)

    31 (67,4)

    63 (58,3)

    0,291

    TNF- alpha

    68,2±23,5

    41,3±17,4

    0,008

    IL-6

    73,1±41,6

    38,0±19,5

    0,003

    IL-10

    6,32±1,3

    6,21±1,4

    0,753

    IFN-gamma

    145±96

    126±92

    0,664

    WBC

    3286±5602

    2275±1286

    0,280

    PLT

    53564±36520

    98065±42768

    0,001

    CRP

    3,2±2,6

    1,1±1,4

    0,005

    ALT

    521±482

    208±320

    0,044

    AST

    869±1182

    256±215

    0,016

    CPK

    1138±970

    676±835

    0,007

    LDH

    1800±1254

    589±271

    0,002

    Conclusion: Cytokines, chemokines, and other inflammatory mediators function in a manner, acting on many different cell types to regulate the host’s immune response. When cytokines present in high concentrations, they might toxic or even lethal effects. In accordance with this view, we have detected increased serum TNF-alpha, IL-6 levels in the patients with severe CCHF.

    Hülya Yilmaz, MD1, Gürdal Yilmaz, Professor2, Ugur Kostakoglu, Assistant professor3, Mustafa Arslan, MD4, Süleyman Caner Karahan, Professor5 and Iftihar Koksal, Professor2, (1)Department of Medical Biochemistry, Health Sciences University, Kanuni Training and Research Hospital, TRABZON, Turkey, (2)Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University, Medical Faculty, Trabzon, Turkey, (3)Department of Infectious Diseases and Clinical Microbiology, Recep Tayyip Erdogan University, Rize, Turkey, (4)Department of Infectious Diseases and Clinical Microbiology, Amasya University Sabuncuoglu Serefeddin Training and Research Hospital, Amasya, Turkey, (5)Department of Medical Biochemistry,, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey

    Disclosures:

    H. Yilmaz, None

    G. Yilmaz, None

    U. Kostakoglu, None

    M. Arslan, None

    S. C. Karahan, None

    I. Koksal, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.