655. An Outbreak of Invasive Group A Streptococcal Infections in Injection Drug Users
Session: Poster Abstract Session: Outbreaks and Public Health Across the Globe
Thursday, October 5, 2017
Room: Poster Hall CD
Posters
  • 655_IDWPOSTER.pdf (735.9 kB)
  • Background: Opioid addiction is a major public health problem, and New Hampshire has the second highest overdose death rate in the nation (34.3 deaths per 100,000 population in 2015 ). In October 2016, the Infectious Disease (ID) service at an acute care hospital in central New Hampshire was consulted on 4 cases of S. pyogenesa.k.a. Group A Streptococcal (GAS) septicemia in injection drug users (IDUs) within less than a week. The cluster was reported to the NH Division of Public Health Services (DPHS) and an outbreak investigation was begun.

    Methods: Additional case finding was instituted by signage in areas of at-risk populations, press releases, and a statewide health alert network (HAN) bulletin to clinicians. DPHS interviewed possible cases using a standardized questionnaire, and cases of invasive GAS reported in the previous 3 months were reviewed. The initial 4 isolates were collected for pulsed field gel electrophoresis (PFGE) and whole genome sequencing (WGS).

    Results: A total of 11 cases of invasive GAS infection in IDUs were identified, 82% of which occurred within the month of October. The most common associated diagnosis was septicemia (90%), followed by cellulitis (67%), sepsis (55%), and pneumonia (18%). Ten (90%) patients were also co-infected with hepatitis C and a majority (55%) were homeless. Three quarters of the initial cases had identical isolates by PFGE and WGS. Two of these individuals were found to have a social connection. Of the 4 sentinel cases, all completed 10 days of parenteral antibiotics with clinical improvement. However, long term outcomes were poor, largely due to sequelae of substance addiction.

    Conclusion: An invasive GAS outbreak was identified in a cluster of IDUs and associated with homelessness, with a majority presenting with septicemia or sepsis. Close cooperation between local clinicians and DPHS was crucial to identifying and determining the scope of this outbreak. GAS is not a well-known but life threatening pathogen in IDUs, and clinicians need increased awareness, especially during an outbreak.

    Jennifer Gittzus, MD1, Joshua White, MD2, Lynda Caine, RN BSN MPH3, Katrina Hansen, MPH4, Elizabeth Daly, MPH5, Benjamin Chan, MD, MPH6, Hannah Bowen, MPH5, Erin Metcalf, MPH5, Lindsay Pierce, M. Ed.5, Rachel Kusch, MA5, Christopher Benton, Ph.D., MB (ASCP)(CM)5, Fenxiang Gao, MD, MPH5, Elizabeth Talbot, MD6,7 and James Noble, MD, FACP8, (1)Infectious Disease, Concord Hospital, Concord, NH, (2)Infectious Disease - Concord Disease, Concord, NH, (3)Infection Prevention, Concord Hospital, Concord, NH, (4)Healthcare-Associated Infections Program, Bureau of Infectious Disease Control/NH Department of Health and Human Services, Concord, NH, (5)New Hampshire Department of Health and Human Services, Concord, NH, (6)Bureau of Infectious Disease Control, New Hampshire Department of Health and Human Services, Concord, NH, (7)Infectious Disease and International Health, Dartmouth Hitchcock Medical Center, Lebanon, NH, (8)Infectious Diseases, Concord Hospital, Concord, NH

    Disclosures:

    J. Gittzus, None

    J. White, None

    L. Caine, None

    K. Hansen, None

    E. Daly, None

    B. Chan, None

    H. Bowen, None

    E. Metcalf, None

    L. Pierce, None

    R. Kusch, None

    C. Benton, None

    F. Gao, None

    E. Talbot, None

    J. Noble, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.