1187. Gastroenteritis Severity - A Prospective Cohort Comparison of Children in Emergency Department and Home Settings
Session: Poster Abstract Session: Enteric Infections and Diagnostics
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • ID week 2017 Poster - Vanderkooi Severity ED vs community v 6.0.pdf (331.3 kB)
  • Background:

    While nearly 2 million children are brought to emergency department (ED) annually due to vomiting and/or diarrhea from acute gastroenteritis (AGE), it is estimated that 90% of AGE cases do not seek medical care. We sought to determine if the disease severity and enteropathogen burden of disease of children with AGE brought for ED care is different from those cared for at home.

    Methods:

    Subjects were prospectively recruited by the APPETITE team in pediatric EDs in 2 urban centers and via HealthLink, a province-wide nurse telephone advice line. Eligibility criteria included: < 18 years old, AGE defined by ≥ 3 episodes of vomiting or diarrhea in the preceding 24 hours, and < 7 days of symptoms. The primary outcome was index encounter disease severity quantified using the modified Vesikari Scale (MVS) score. To eliminate the impact of the index encounter on the score we excluded the index ED visit and intervention from all calculations. Secondary objectives included the enteropathogen burden of disease. Two rectal swabs and stool were collected and tested for enteropathogens by enteric bacterial culture, Luminex xTAG GPP, and a 5-virus in-house RT-qPCR panel.

    Results:

    Between Dec 9, 2014 and Dec 31, 2016, 1,623 participants were enrolled with 81.5% from the EDs. Median age was 20.1 months. Children who went to ED were less likely to have a family physician (62 vs 82%, P<0.001), more likely to have clinical dehydration (Clinical Dehydration Scale score 3 vs 1, P<0.001) and vomiting (91 vs 85%, P=0.004), previously received IV fluids (4.1 vs 0.7%, P=0.001) or been admitted (5.4 vs 1.3%, P=0.002). The MVS score was similar between groups when the contribution of the index visit to the score was excluded (8.1 vs 7.8, P=0.15). Participants recruited in the ED were not significantly more likely to have bacterial pathogens (8.0 vs 3.7%, P=0.09) but were less likely to have viral pathogens identified (64.1 vs 80.7, P<0.001).

    Conclusion:

    Children presenting for ED care had disease severity scores that were similar to children managed at home when the contribution of the index ED visit was accounted for. Viral pathogens were more common in AGE receiving care at home while those presenting to the ED and potentially have a clinically greater likelihood of having a bacterial enteropathogen.

    Otto G. Vanderkooi, MD1, Jianling Xie, MD, MPH2, Bonita Lee, MD MSc FRCPC3, Samina Ali, MDCM3, Xiao-Li Pang, PhD3, Linda Chui, PhD4, Daniel C. Payne, PhD, MSPH5, Phillip Tarr, MD, FIDSA6, Ran Zhuo, PhD3, Brendon Parsons, PhD4, Lara Osterreicher, RN7, Kelly Kim, BSc8 and Stephen Freedman, MDCM8, (1)The University of Calgary, Calgary, AB, Canada, (2)Alberta Children's Hospital, Calgary, AB, Canada, (3)University of Alberta, Edmonton, AB, Canada, (4)Laboratory Medicine & Pathology, University of Alberta, Edmonton, AB, Canada, (5)Centers for Disease Control and Prevention, Atlanta, GA, (6)Pediatric Gastroenterology, Washington University, St. Louis, MO, (7)Alberta Health Services, Calgary, AB, Canada, (8)University of Calgary, Calgary, AB, Canada

    Disclosures:

    O. G. Vanderkooi, None

    J. Xie, None

    B. Lee, None

    S. Ali, None

    X. L. Pang, None

    L. Chui, None

    D. C. Payne, None

    P. Tarr, None

    R. Zhuo, None

    B. Parsons, None

    L. Osterreicher, None

    K. Kim, None

    S. Freedman, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.