1066. Title: Trends in the burden and seasonality of rotavirus in the United States, 2000-2016
Session: Poster Abstract Session: Assorted Pediatric Vaccines
Friday, October 6, 2017
Room: Poster Hall CD
Background: Before implementation of rotavirus vaccination in 2006, rotavirus caused 55,000-70,000 hospitalizations and 410,000 clinic visits annually in US children. This report examines the long-term impact of vaccine introduction on rotavirus detection and seasonality through comparison of pre (2000-2006) and post (2007-2016) vaccine seasons through the National Respiratory and Enteric Virus Surveillance System (NREVSS).

Methods: NREVSS is a passive laboratory system collecting results of weekly total and rotavirus-positive stool specimens. Seasons are defined as July through June. To characterize changes in rotavirus detection, total and positive specimens for each post vaccine season from 11 continuously reporting (≥26 weeks per season) laboratories were compared to median values for 2000-2006. Data from 20 participating laboratories were used to determine changes in season characteristics. ArcGIS software was used to document the annual geographic trend across the United States between 2000-2015. For season 2015-2016, data are available through April and are not included in the ArcGIS analysis.

Results: Nationally, there was a 53-93% reduction in rotavirus positivity in the post vaccine period as compared to the median in 2000-2006. Trends in rotavirus positivity declined steeply after vaccine introduction in 2006, and have remained low compared to the pre-vaccine period, with alternating years of lower and greater activity (figure). All regions had similar reductions in positive tests. ArcGIS data indicate that peak seasonal activity was largely restricted to January-April for each pre-vaccine year. In the 2006-2007 season, peak activity occurred during January-April, for 2007-2008, this shifted to March-April, for 2008-2009, the peak activity nationwide occurred at all months of the year from the reporting laboratories. This diffuse activity occurred for all subsequent years, save 2009-2010 and 2012-2013, where peak seasonal activity was again confined to January-April.

Conclusion: Rotavirus vaccine substantially and sustainably reduced the burden and changed the epidemiology of rotavirus in US children. The biennial pattern observed may be explained by accumulating unvaccinated children over two successive seasons resulting in stronger rotavirus seasons every alternate year.

Negar Aliabadi, MD MS1, Amber Haynes, MPH2, Jacqueline Tate, PhD3, Umesh D. Parashar, MBBS, MPH3 and Aaron T. Curns, MPH3, (1)National Center for Immunization and Respiratory Diseases, Centers for Disease Control and Prevention, Atlanta, GA, (2)IHRC Inc, contracting agency to Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA, (3)Division of Viral Diseases, Centers for Disease Control and Prevention, Atlanta, GA

Disclosures:

N. Aliabadi, None

A. Haynes, None

J. Tate, None

U. D. Parashar, None

A. T. Curns, None

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