1059. Measles, Mumps, and Rubella Antibody: Patterns of Persistence and Rate of Decline Following the Second Dose of the MMR Vaccine
Session: Poster Abstract Session: Assorted Pediatric Vaccines
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • Seagle_IDweek_MMR persistence_2017.pdf (410.0 kB)
  • Background: Antibodies to measles, mumps, and rubella decline an estimated average of 3% per year, and have a high degree of variation among individuals. Yet, this variation and differences in individual level response to the 3 antigens are not well understood. To better understand potential implications on individual and population-level susceptibility, we reanalyzed existing longitudinal data to identify patterns of seropositivity and antibody persistence.  

    Methods: Wisconsin children given the second dose of measles, mumps, and rubella vaccine (MMR2) at age 4-6 years were followed up to 12 years postvaccination. The rate of antibody decline and factors associated with the rate of decline were assessed using regression models that accounted for differences between and among subjects.

    Results: Most of the 302 participants were seropositive throughout follow-up (96% measles, 88% mumps, 79% rubella). The rate of antibody decline was associated with MMR2 response and baseline titer for measles and age at first dose of MMR (MMR1) for rubella. None of the demographic or clinical factors examined were associated with rate of decline for mumps. One month after MMR2, geometric mean titer (GMT) to measles was high (3892 mIU/mL), but declined on average 9.7% per year among subjects with the same baseline titer and <2 fold increase in antibody titer after MMR2. Subjects with ≥2 fold increase experienced a slower decline (≤7.4%). GMT to rubella was 149 IU/mL one month after MMR2 and declined 2.6% and 5.9% per year among those who received MMR1 at 12-15 months and >15 months, respectively. GMT to mumps one month after MMR2 was 151 and declined 9.2% per year. Only 14% of participants had the same trends in antibody persistence for all 3 antigens.

    Conclusion: The rate of antibody decay varied substantially among individuals and among the 3 antigens. Despite waning titers, measles and rubella antibody levels remained high 12 years post MMR2. However, a fast rate of decline and high degree of variation was observed for mumps, yet no predictors of the decline were identified. Future research should focus on better understanding waning antibody titers to mumps and its impact on community protection and individual susceptibility, in light of recent mumps outbreaks in vaccinated populations.

    Figure 1. Measles

     

     

     

    Figure 2. Mumps

     

     

     

     

     

     

     

     

     

    Figure 3. Rubella

     

     

    Emma Seagle, MPH1,2, Robert Bednarczyk, PhD2, Tenisha Hill, MPH1, Amy Parker Fiebelkorn, MSN, MPH3, Carole Hickman, PhD3, Joseph Icenogle, PhD3, Edward Belongia, MD1 and Huong Q. Mclean, PhD, MPH1, (1)Marshfield Clinic Research Institute, Marshfield, WI, (2)Rollins School of Public Health, Emory University, Atlanta, GA, (3)Centers for Disease Control and Prevention, Atlanta, GA

    Disclosures:

    E. Seagle, None

    R. Bednarczyk, None

    T. Hill, None

    A. P. Fiebelkorn, None

    C. Hickman, None

    J. Icenogle, None

    E. Belongia, None

    H. Q. Mclean, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.