1772. Uropathogens and antibiotic resistance among nursing home residents - National Healthcare Safety Network (NHSN)
Session: Oral Abstract Session: National Trends in HAIs
Saturday, October 7, 2017: 9:30 AM
Room: 08

Background: Knowledge of urinary tract infection (UTI) pathogen and susceptibility patterns is necessary to inform antibiotic prescribing and monitor resistance.  We describe bacterial pathogens and UTI antibiotic resistance patterns among residents in nursing homes (NHs) reporting to the National Healthcare Safety Network (NHSN) long term care facility (LTCF) component.

Methods: All UTI events from January 1, 2013 to December 31, 2016 were included; up to 3 organisms per UTI event may be reported.  Pathogen susceptibility results for selected antibiotics are reported as: Susceptible (S), Intermediate (I), Resistant (R), or Not tested (N). For this analysis, resistance was defined as I or R. We described pathogens and summarized antibiotic resistance only when ≥100 isolates of a bacterial species had susceptibility test results for a particular antibiotic reported to NHSN. 

Results: In 166 NHs located in 37 states, a total of 4,054 pathogens were reported for 2,827 residents. Six organisms accounted for 81% of all UTI events (n=3,599) (Table). A large proportion of Escherichia coli isolates, which accounted for 41% of uropathogens, were resistant to trimethoprim-sulfamethoxazole (35%) and levofloxacin (50%). Among Proteus mirabilis isolates, 53% were resistant to levofloxacin (Figure).  Methicillin resistance was 74% among Staphylococcus aureus, and vancomycin resistance among Enterococcus spp. was 18%.

Conclusion: This is the first summary of UTI pathogens and susceptibility data from U.S. nursing homes reporting to a national surveillance system. Resistance to antibiotics commonly used to treat UTIs was high. Tracking and preventing resistance for key pathogens is a CDC priority and NHSN reporting by NHs provides a crucial opportunity to track antibiotic resistance, highlighting the importance of enrolling more NHs into NHSN. 

Table. Top Nursing Home Uropathogens - NHSN, January 2013 – December 2016

Pathogen

N

%

Escherichia coli

1648

41

Proteus mirabilis

524

13

Enterococcus spp.

441

11

Klebsiella pneumoniae

412

10

Pseudomonas aeruginosa

256

6

Staphylococcus aureus

122

3

Note: Enterococcus spp. includes E. faecium and E. faecalis. 

 

Taniece Eure, MPH1, Nimalie D. Stone, MD, MS1, Nicola D. Thompson, PhD, MSc1, Jeneita Bell, MD MPH2 and Elisabeth Mungai, MPH1, (1)Division of Healthcare Quality Promotion, Centers for Disease Control and Prevention, Atlanta, GA, (2)Centers for Disease Control and Prevention, Atlanta, GA

Disclosures:

T. Eure, None

N. D. Stone, None

N. D. Thompson, None

J. Bell, None

E. Mungai, None

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