472. Instituting Public Health Laboratory Surveillance for Methicillin-resistant Staphylococcus aureus (MRSA), Extended-Spectrum Beta Lactamase producing Enterobacteriaceae (ESBL), and Carbapenem-resistant Enterobacteriaceae (CRE) in a Large Metropolitan County
Session: Poster Abstract Session: HAI: Surveillance + Reporting
Thursday, October 5, 2017
Room: Poster Hall CD
  • Instituting public health laboratory surveillance for MRSA ESBL and CRE.pdf (851.1 kB)
  • Background:

    The community spread of multi drug resistant organisms (MDROs) presents a significant local public health threat. The Orange County Health Care Agency (OCHCA) is collaborating with the Centers for Disease Control and Prevention (CDC) on a countywide decolonization collaborative involving 38 healthcare facilities. To characterize our county's MDRO epidemiology and assess the effectiveness of these efforts, the OCHCA instituted local mandatory reporting for Methicillin-resistant Staphylococcus aureus (MRSA), extended-spectrum beta lactamase producing Enterobacteriaceae (ESBL), and carbapenem-resistant Enterobacteriaceae (CRE).


    In July 2016 a health officer order was signed requiring all laboratories serving any county hospital, long term acute care hospital (LTAC), or skilled nursing facility (SNF), to report all ESBL- and CRE-positive laboratory results, and all inpatient MRSA-positive reports to OCHCA. For this analysis, we reviewed reports received from July 2016-March 2017.


    12 laboratories serving 24 of 32 hospitals, all 3 LTACs, and 65 of 72 SNFs have been routinely reporting electronically. To date, we validated MDRO data from 13 hospitals, all LTACs, and all SNFs by comparing with  parallel reporting systems. Validated hospitals reported 98 MRSA- and 115 ESBL-positive blood culture events. SNFs reported 754 ESBL-culture positive events from all culture types.

    Table 1. MDROs Reported to OCHCA


    MDROs are significant causes of invasive disease in Orange County.  ESBL colonization or infection was commonly identified in SNF residents, highlighting the need for improved infection control and antibiotic use in these settings. Community-wide surveillance provided objective data to assess the magnitude of MDROs.  Local public health surveillance for CRE, ESBL, and MRSA can be effectively instituted in a large community, but is resource-intensive and requires extensive facility outreach.

    Kathleen O'Donnell, MPH1,2, Eric Handler, MD, MPH3 and Matthew Zahn, MD, FIDSA2, (1)California Department of Public Health, Santa Ana, CA, (2)Epidemiology and Assessment, Orange County Health Care Agency, Santa Ana, CA, (3)CDPH, Santa Ana, CA


    K. O'Donnell, None

    E. Handler, None

    M. Zahn, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.