1037. Herpes-zoster infection in a tertiary hospital in Brazil
Session: Poster Abstract Session: Adult Viral Infection
Friday, October 6, 2017
Room: Poster Hall CD

Background: herpes zoster (HZ) is a common infection with potential complications requiring hospital care, especially for patients with multiple comorbities. However, there is little information on HZ from hospital registries.

Methods: we searched for hospital-based records of B02 code (ICD-10) between March, 2000 and January, 2017 at Hospital de Clínicas de Porto Alegre, a tertiary, university hospital in south Brazil. To avoid misclassifications, we considered clinical evaluation for the diagnosis of cutaneous HZ and postherpetic neuralgia (PHN), ophthalmological evaluation for ophthalmic HZ and the combination of clinical, radiologic and cerebrospinal fluid analysis for HZ meningo-encephalitis (ME). We analyzed conditions associated with immune dysregulation, complications, length of hospital stay, and mortality. Chi-square test and Kaplan-Meier estimator were used for statistical analyses. p<0.05 was considered statistically significant.

Results: there were 847 records for this period, of which 801 were confirmed according to our criteria and included in the analysis. Most patients were women (n=448; 60%), with an average of 48.8 years, standard deviation of 22.2. There were more diagnoses in the inpatients group (74.4%), and fewer in the emergency room (22.4%) and outpatient (3.3%). The median length of hospital stay was 7 days (2-10, P25-P75) when HZ was the main reason for admission. Most patients presented cutaneous HZ (n=743, 92.8%). There were fewer cases of PHN (6.1%), ophthalmic HZ (7.6%) and ME (4.1%). Seventy percent had some kind of immune dysregulation; more frequently AIDS (31%), use of immunosuppressive agents (18.7%) and malignant disease (16.2%). We followed the subjects for a median of 28.2 (2.8-77.5) months. During this period, there were 105 (13.1%) deaths. Five were related to HZ ME. The 30-day overall mortality rate was 1.5%. There was no statistical difference in cumulative survival (graph 1, p=0.05) or incidence of complicated forms for patients with or without immune dysregulation.
Conclusion: our sample was characterized by a majority of inpatient diagnoses. The 30-day mortality rate was lower than reported in similar studies, but there was a relevant impact of complicated forms in mortality and sequelae.

Luciana Antoniolli, Medical student1, Aline Azambuja, MD, PhD2, Camila Rodrigues, Medical student1, Rafael Borges, medical student1 and Luciano Goldani, PhD, MD3, (1)Federal University of Rio Grande do Sul, Porto Alegre, Brazil, (2)Infectious Diseases, Federal University of Rio Grande do Sul, Porto Alegre, Brazil, (3)Internal Medicine, Infectious Diseases Unit, Hospital de Clinicas de Porto Alegre, Porto Alegre, Brazil

Disclosures:

L. Antoniolli, None

A. Azambuja, None

C. Rodrigues, None

R. Borges, None

L. Goldani, None

Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.