672. Comparative Analysis of Incidence and Outcomes of Acute Hepatitis A (HAV) and B Virus Infections (HBV) in Children Aged ≤ 20 years in the United States (US)
Session: Poster Abstract Session: Outbreaks and Public Health Across the Globe
Thursday, October 5, 2017
Room: Poster Hall CD
Background:

HAV and HBV are amongst the most common vaccine preventable diseases and may be associated with morbidity and health care costs. The epidemiology and impact of acute HAV and HBV infection in pediatric hospitalizations is poorly defined relative to other populations.

Methods:

A cohort study was undertaken with the 2012 Kids’ Inpatient Database that encompasses a stratified random sample of community and non-rehabilitation based hospitalizations across the US of pediatric patients aged ≤ 20 years. The primary outcome was incidence of acute HAV and HBV related hospitalizations. Risk factors of age, sex, and race, and outcomes of length of stay (LOS), and costs were compared between persons with HAV and HBV infection. ICD-9 codes of 070.0 - 070.31 were utilized to capture acute HAV and HBV cases. Continuous and discrete outcomes between HAV and HBV were calculated with linear and logistic regression (with weighting), respectively.

Results:

A total of 424 cases of acute viral hepatitis A (48.3%), B (50.5%), and co-infection (1.2%) occurred, corresponding to a national overall incidence rate of 8.9 cases per 100,000 persons (aged ≤ 20 years). HBV acquisition was associated with a higher mean age than HAV (15.4 versus 13.1 years, p<0.001). A greater proportion of patients with HBV compared to HAV were female (70.1% vs 41.2%, p < 0.001). The distribution of race was significantly different with disproportionate numbers of HBV compared with HAV cases in Blacks and Asians (p < 0.001). LOS (6.93 vs 4.38 days, p =0.02) and hospitalization costs ($58,211 vs $30,758, p =0.03) were both significantly greater in HBV than HAV cases.

Conclusion:

We demonstrated that acute HAV and HBV cases differed in demographic factors of sex, age, and race, and that HBV was associated with greater LOS and costs. Although the incidence was low, enhanced vaccine efforts are indicated for further prevention of these infections in children.

Brett Edwards, M.D., Department of Medicine, University of Calgary, Calgary, AB, Canada, Abdel Aziz Shaheen, MD, Medicine - Gastroenterology, University of Calgary, Calgary, AB, Canada, Michael Parkins, MD, Department of Medicine; Division of Microbiology & Infectious Diseases, University of Calgary, Calgary, AB, Canada and Ranjani Somayaji, M.D., Department of Medicine;, University of Calgary and Alberta Health Services - Calgary zone, Calgary, AB, Canada

Disclosures:

B. Edwards, None

A. A. Shaheen, None

M. Parkins, None

R. Somayaji, None

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