1283. Impact of Clostridium difficile infection on patients’ quality of life: a French Hospital prospective study
Session: Poster Abstract Session: HAI: C. difficile Epidemiology, Impact, and Testing
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • 2014-076 MSD Poster ICD CDIFF32 paysage VF-21-09-17 [Lecture seule].pdf (149.4 kB)
  • Background:

    Few data are available on the impact of episodes of Clostridium difficile infection (CDI) on quality of life. The Cdiff32, a new specific health-related quality of life questionnaire recently validated, allows such a measurement (Garey et al. J Clin Gastroenterol 2016 Sep;50(8):631-7).

    Methods:

    An observational prospective study was performed in 7 French acute-care facilities in 2016. All consecutive patients presenting with a bacteriologically-confirmed CDI during a hospital stay, regardless of reason for hospitalization, were enrolled. Two instruments were presented to patients at 7(+/-2) days after CDI diagnosis: the Cdiff32 and a generic questionnaire the EQ-5D-3L. The Cdiff32 comprises 32 self-administered questions about the impact of CDI in 3 broad domains (physical, mental and social). The physical domain differentiates general (6 questions) and specific physical complaints (8 questions). The mental domain comprises 14 questions about current and future anxiety. Four questions cover the impact on social relationships. Each item is scored from 0 (worst score) to 100 (best score) and they are aggregated by domain and globally. Clinical variables were collected to characterize the infection severity (ZAR score) and comorbidities. A regression analysis of the Cdiff32 scores with the EQ-5D-3L was performed.

    Results:

    80 patients were enrolled and 3 were excluded because of missing data. The median age was 71 years and 45% were males. The global Cdiff32 score was 50.4 (SD: 17.1) with a large variability among patients (min 18.3, max 90.2). The highest impact of CDI was observed on the general physical complaints (41.6), as well as the level of current anxiety (41.6). The score relating to the social relationships was the highest (63.7). The severity of CDI (as defined by the Zar score) and the global Cdiff32 score were correlated essentially through the physical sub-score (p=0.0154). Patients with recurrences had a lower mental score compared to patients with an initial episode (p=0.0582). The regression analysis of global Cdiff32 score and EQ-5D-3L utility score showed a positive relationship (R2=0.317).

    Conclusion:

    The Cdiff32 allowed to estimate the important impact on quality of life of CDI especially on the physical domain.

    Frederic Barbut, PharmD, PhD1, Tatiana Galperine, PharmD, PhD2, Philippe Vanhems, MD, PhD3, Alban Le Monnier, PharmD, PhD4, Viviane Jeanbat, PhD5, Anne Duburcq, MSc5, Sarah Alami, MSc6, Caroline Bensoussan, MD6 and Francis Fagnani, PhD5, (1)75, National Reference Laboratory for Clostridium Difficile - Assistance Publique-Hôpitaux de Paris - Hôpital Saint Antoine, Paris, France, (2)59, CHU Lille, Maladies Infectieuses, Lille, France, (3)69, Groupement hospitalier Edouard Herriot, Hospices civils de Lyon, Lyon, France, (4)Groupement hospitalier Paris Saint-Joseph, Paris, France, (5)CEMKA-EVAL, Bourg la Reine, France, (6)MSD France, COURBEVOIE Cédex, France

    Disclosures:

    F. Barbut, None

    T. Galperine, None

    P. Vanhems, None

    A. Le Monnier, None

    V. Jeanbat, None

    A. Duburcq, None

    S. Alami, None

    C. Bensoussan, None

    F. Fagnani, None

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.