Methods: A prospective study of breastfeeding mothers prescribed antibiotics, and their nursing infant. Breast milk and infant fecal samples were collected at six different time points before, during and after maternal antibiotic treatment. The glycobiome and gut microbiota were characterized by 16S ribosomal RNA gene sequencing. Antibiotic concentrations in breast milk were determined by HPLC. Demographic data and relevant medical information was obtained from participants.
Results: 22 mother-infant pairs completed the study (mean age of infants 4 months, SD 2,4). Antimicrobial consumption resulted in rapid reduction in alpha diversity in breast milk, with partial recovery by 30 days post antibiotic treatment. Infant gut microbiome showed distinct changes after maternal treatment which were mainly characterized by a decrease in the relative abundance of Bifidobacteria and Veillonella.
Conclusion: Our preliminary study clearly showed a disruptive effect of maternal antibiotic consumption on the nursing infant’s gut microbiome with an impact on the important early colonizers of the infant gut. Larger studies comparing the effect of different antibiotics on infant gut microbiome are needed, in addition to available safety data, to make informed recommendations about specific antibiotic use in breastfeeding women.
H. Neuman, None
H. Hanya, None
O. Koren, None
I. Youngster, None