1153.  The prognostic importance of platelet indices in patients with Crimean-Congo Hemorrhagic Fever
Session: Poster Abstract Session: Diagnostics: Biomarkers
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • The prognostic importance of platelet indices in patients with Crimean-Congo Hemorrhagic Fever.pdf (331.9 kB)
  • Background:

    Platelet count is an important tool for the diagnosis and prognosis of Crimean-Congo Hemorrhagic Fever (CCHF). The platelet indices plateletcrit, mean platelet volume (MPV) and platelet distribution width (PDW) are parameters obtained as part of the automated complete blood count. These parameters are of prognostic importance in several diseases. The aim of this study was to evaluate the platelet count and its relations with platelet indices in CCHF patients.

    Methods:

    One hundred and forty-nine patients with confirmed CCHF were included in the study. Patients were divided into two groups (severe cases, patients who exhibited hemorrhage during their hospital stay, and mild/moderate cases with no hemorrhage during hospital stay). The demographic characteristics and laboratory test results of all patients were compared. p<0.05 was regarded as statistically significant.

    Results:

    Hemorrhaging was observed in 38.3% of patients during hospitalization. Platelet count, PCT and PDW values (respectively) on the first day of hospitalization were 43.3±29.3, 0.06±0.07%, and 17.4±1.5% in the severe cases and 64.5±35.4, 0.08±0.03%, and 16.8±1.5% in the mild/moderate cases, respectively (P<0.05). The difference between MPV values was not statistically significant. At cutoff values at ROC analysis, platelet count (≤53000) and PCT(≤0.06) exhibited 73.7% and 71.9% sensitivity, respectively, and predicted a hemorrhagic disease course with a 80.9% negative predictive value. Seven of the severe patients died (p=0.001). At cutoff values, platelet count (>31000) and PCT (>0.03) predicted patient survival with 100% specificity and 100% positive predictive value.

    Table 1: Demographic and laboratory characteristics of patients with severe and mild/moderate CCHF

    Severe cases

    n=57

    Mild/moderate cases

    n=92

    p-value

    Age

    45.8±15.6

    51.8±17.1

    0.034

    Female, n (%)

    35 (61.4)

    38 (41.3)

    0.017

    Blood/blood product transfusion

    39

    42

    0.007

    IVIG

    14

    5

    0.002

    Mortality

    7

    0

    0.001

    PLT

    43.3±29.3

    64.5±35.4

    <0.0001

    PCT

    0.06±0.07

    0.08±0.03

    0.001

    PDW

    17.4±1.5

    16.8±1.5

    0.040

    MPV

    8.6±1.3

    8.6±1.2

    0.782

    Conclusion:

    Our study shows that platelet count, PCT and PDW are parameters that may be used to determine disease severity. The platelet index, and particularly PCT, may be at least as useful as platelet count in helping clinicians identify severe cases.

    Firdevs Aksoy, Assistant Professor1, Gürdal Yilmaz, Professor1, Selcuk Kaya, Associate Professor1, Süleyman Caner Karahan, Professor2 and Iftihar Koksal, Professor1, (1)Department of Infectious Diseases and Clinical Microbiology, Karadeniz Technical University, Medical Faculty, Trabzon, Turkey, (2)Department of Medical Biochemistry,, Karadeniz Technical University, Faculty of Medicine, Trabzon, Turkey

    Disclosures:

    F. Aksoy, None

    G. Yilmaz, None

    S. Kaya, None

    S. C. Karahan, None

    I. Koksal, None

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