880. Characterization of New HIV Infections among Adults ≥45 Years — New York City, North Carolina, San Francisco, 2011–2013.
Session: Oral Abstract Session: Preventing and Identifying New HIV Infections
Thursday, October 5, 2017: 2:15 PM
Room: 07AB

Background:

While HIV prevention activities are often focused on younger people, older people can also be at risk for HIV infection. We aimed to characterize HIV transmission in older adults.

Methods:

The STOP study was a multi-site prospective study of persons with acute HIV infection (AHI) from 2011 to 2013. Older adults were defined as ≥ 45 years and younger persons were 13-44 years. AHI was defined by a negative rapid test but a reactive antigen/antibody or HIV RNA test. We performed bivariate analysis using Pearson’s chi-square and odds ratios to examine associations between older age and transmission characteristics. Among persons with HIV-1 polymerase (pol) sequences, transmission linkages were inferred when the genetic distance between sequences was <1.5% and did not indicate directionality of transmission.  

Results:

Among 86,836 participants (median age, 29 years; 75.0% male; 51.8% MSM), HIV infection was diagnosed in 176 (1.46%) of 12,036 older adults compared with 1,150 (1.53%) of 74,800 younger people (p = 0.56). Among HIV-infected persons, AHI was diagnosed in similar proportions of older and younger people (13.1% vs. 12.6%; p=0.86). Among HIV-infected persons who participated in partner notification (n=1,326), older adults were less likely to report meeting a sex partner online (11.3% vs. 26.9%; OR 0.52, 95% CI=0.35-0.78) and were less likely to name ≥2 sex partners (31.5% vs. 46.8%; OR=0.28, 95% CI=0.15-0.53) compared with younger people. Among HIV-infected persons with HIV-1 pol sequences (n=537), similar proportions of older and younger people had viruses that genetically linked with another study participant (15.9% vs. 23.5%; OR 0.62, 95% CI 0.31–1.22) [Figure].

Conclusion:

In this study older adults had a similar frequency of newly diagnosed HIV infection, acute infection, and genetic linkage compared with younger people, suggesting increased HIV prevention efforts may be needed in this population.

 

Mary Evans, MD, MPH1, Anne Patala, MPH2, Ellsworth Campbell, MS3, Emily Westheimer, MS4, Cynthia L. Gay, MD, MPH5, Stephanie E. Cohen, MD, MPH6, William M. Switzer, MPH3 and Philip J. Peters, MD3, (1)Division of HIV and AIDS Prevention, Centers for Disease Control and Prevention, Atlanta, GA, (2)Division of HIV and AIDS Prevention, ICF International, Atlanta, Georgia and Centers for Diseae Control and Prevention, Atlanta, GA, (3)Centers for Disease Control and Prevention, Atlanta, GA, (4)Bureau of HIV Prevention and Control, New York City Department of Health and Mental Hygiene, Queens, NY, (5)North Carolina Department of Public Health, Raleigh, NC, (6)Population Health, San Francisco Department of Public Health, San Francisco, CA

Disclosures:

M. Evans, None

A. Patala, None

E. Campbell, None

E. Westheimer, None

C. L. Gay, None

S. E. Cohen, None

W. M. Switzer, None

P. J. Peters, None

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