2343. Congenital Neurological Disorders in Children with Microcephaly Related to Exanthematous Diseases During Pregnancy: A Cohort Study
Session: Poster Abstract Session: Pediatric Virology
Saturday, October 7, 2017
Room: Poster Hall CD
  • Congenital Neurol POSTER IDWEEK 17.pdf (548.0 kB)
  • Background: An increase in the prevalence of microcephaly (MCP) was seen in Rio Grande do Norte State (RN) since September 2015. This Brazilian northeast state was highly impacted by a Zika (ZIKV) outbreak in the last 2 years. The highest rate of MCP was in November 2015 with 20.1 cases per 1,000 live births, compared to 1.8 cases/year in the previous years. Our study aimed to evaluate the neurological disorders in children with microcephaly whose mothers had exanthematous disease (ED) during the pregnancy.

    Methods: We evaluated children up to 17 months old followed at a children rehabilitation center in RN. Cohort enrollment occurred with children born between January 2015 and May 2016. We interviewed their mothers about the occurrence of ED during their pregnancy.

    Results: Of the 37 cases of MCP (25 male, 12 girls), 10 mothers did not know how to describe presence of ED during pregnancy. Of the 24 cases of MCP with maternal ED, 9 patients were classified as having severe spasticity (Ashworth score 3 and 4), 4 patients were classified as mild (Ashworth score 1e 2) and 11 had no spasticity. Eleven patients had seizure disorders and 5 reported irritability.

    Conclusion: According to this data, there is a high prevalence of neurological complications in children with MCP related to ED. These patients need close follow-up care and intensive medical interventions. Longer follow-up will provide data regarding these chronic neurological complications and how best to intervene.

    Tabata De Alcantara, MD, MS1, Kalyana E. Fernandes, MD2, Jessika Thais Da Silva Maia, MS3, Gleysson Rosa, RN , MD4, Marcelo Rodrigues Zacarkim, MD, MS4, Raquel Duarte Rolim, MS5, Igor Thiago Queiroz, MD, PhD6, David Aronoff, MD, FIDSA7, A. Desiree Labeaud, MD, MS8 and Nilson N. Mendes Neto, MD9,10, (1)CRI-RN, Natal, Brazil, (2)CRI - RN, Natal, Brazil, (3)Universidade Potiguar, Natal - RN, Brazil, (4)Harvard Medical School, Boston, MA, (5)FCM - Campina Grande, PB, Campina Grande, Brazil, (6)Universidade Potiguar, natal, Brazil, (7)Medicine, Vanderbilt University School of Medicine, Division of Infectious Diseases, Nashville, TN, (8)Pediatric Infectious Diseases, Stanford University, Stanford, CA, (9)Extension Center, University of California, Davis, Davis, CA, (10)Family Medicine, HUOL, Natal - RN, Brazil


    T. De Alcantara, None

    K. E. Fernandes, None

    J. Thais Da Silva Maia, None

    G. Rosa, None

    M. Rodrigues Zacarkim, None

    R. D. Rolim, None

    I. Thiago Queiroz, None

    D. Aronoff, None

    A. Desiree Labeaud, None

    N. N. Mendes Neto, None

    See more of: Pediatric Virology
    See more of: Poster Abstract Session

    Findings in the abstracts are embargoed until 12:01 a.m. PDT, Wednesday Oct. 4th with the exception of research findings presented at the IDWeek press conferences.