1485. Community Acquired Pneumonia Incidence Among Children Under 5 Years of Age in Concordia Argentina. Universal Vaccination Impact
Session: Poster Abstract Session: Pneumococcal Immunization and Epidemiology-Global
Friday, October 6, 2017
Room: Poster Hall CD
Posters
  • IDWeeK.pdf (703.8 kB)
  • Background: In January 2012, Argentine introduced PCV-13 to the National Immunization Program. We performed an epidemiological study in order to describe consolidated pneumonia and pneumococcal disease incidence following PCV-13 routine vaccination.

    Methods:

    Between April2014-March2016, a population-based surveillance study was carried out in Concordia. Clinical data, vaccination status and digital chest X-rays were recorded from children < 5 years old with pneumonia and pleural effusion. A pediatrician and a radiologist interpreted the images independently. A second reference radiologist arbitrated when discordances occurred. Bacterial etiology was investigated in blood and/or in pleural fluid. Probably bacterial pneumonia (PBP) was determined following WHO protocol. Results were compared with previous data (2002-2005) from the pre-PCV-13 vaccination era. Variables associated to consolidated pneumonia were evaluated by multivariate analysis using logistic regression

    Results:

    330 patients under 5 years old with pneumonia were assisted during the study period. Of these, 92 (27.9%-IC95% 23.2-33.1) were classified as PBP. Annual incidence rate, in pre and post vaccination period and impact of vaccination are described in table 1. Incidence of pneumococcal disease could not be estimated as pneumococcal isolation was negative in all cases.

    Multivariate analysis of post-PCV-13 vaccination era showed that incidence of consolidated pneumonia was significantly higher in hospitalized toddlers than outpatients OR: 2,97 (1,65-5,38). Table N°1: PBP incidence (*100.000) by study period. Vaccination impact

    Final Classification

    PRE-VACCCINATION

    PERIOD

    POST VACCINATION

    PERIOD

    IMPACT OF VACCINATION

    N

    Population

    Incidence

    n

    Population

    Incidence

    Incidence Rate ratio (IC95%)

    Decrease

    P value

    Consolidated pneumonia

    387

    18.053

    714,6

    86

    15.493

    283,9

    2,5

    (1,8-3,6)

    60,2%

    <0,001

    Pneumonia with pleural effusion

    72

    18.053

    132,9

    6

    15.493

    19,4

    6,7

    (2,1-35,6)

    85,4%

    0,004

    PBP (total)

    459

    18.053

    847,5

    92

    15.493

    296,9

    2,8

    (2-4)

    64,9%

    <0,001

    Conclusion:

    A significant decline in consolidated pneumonia and pleural effusion incidence in <5 year old children was evidenced in Concordia after the introduction of PCV13 into national immunization program.

    Analía Rearte, MD1, Raul Ruvinsky, MD2, Judit Kupervaser, MD3, Luis Fernando Gentile, MD4, Maria Eugenia Cafure, MD5, Adriana Haidar, MD3, Maria Elisa Tito, MD6, Federico Avaro, MD7, Cristina Cortiana, MD8, Hugo Cozzani, MD9, Omar Veliz, Biochemistry10, Sofia Fossati, Biochemistry11, Mabel Regueira, MD12 and Carla Vizzotti, MD13, (1)Ministerio de Salud de la Nación, Buenos Aires, Argentina, (2)1Ministerio de Salud de la Nación, Buenos Aires, Argentina, (3)Hospital Delicia Concepción Masvernat, Concordia, Argentina, (4)Hospital de Niño Ricardo Gutiérrez, Buenos Aires, Argentina, (5)Centro provincial de salud Constitución, Concordia, Argentina, Concordia, Argentina, (6)Hospital Delicia Concepción Masvernat,, Concordia, Argentina, (7)Hospital Felipe Heras, Concordia, Argentina, (8)Hospital Ramón Carrillo, Concodia, Argentina, (9)Hospital de niños Ricardo Gutiérrez, Concrodia, Argentina, (10)National Institute of Infectious Diseases- ANLIS “Dr. Carlos G. Malbran”, Buenos Aires, Argentina, (11)National Institute of Infectious Diseases - ANLIS “Dr. Carlos G. Malbran, Buenos Aires, Argentina, (12)Servicio Bacteriologia Clinica, Instituto Nacional de Enfermedades Infecciosas ANLIS "Dr. Carlos G Malbran", Buenos Aires, Argentina, (13)Ministerio de Salud de la Nación (2007-2016), Buenos Aires, Argentina

    Disclosures:

    A. Rearte, None

    R. Ruvinsky, None

    J. Kupervaser, None

    L. F. Gentile, None

    M. E. Cafure, None

    A. Haidar, None

    M. E. Tito, None

    F. Avaro, None

    C. Cortiana, None

    H. Cozzani, None

    O. Veliz, None

    S. Fossati, None

    M. Regueira, None

    C. Vizzotti, None

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