315. Clinical manifestations, hematology, and chemistry profiles of the six most common etiologies from an observational study of acute febrile illness in Indonesia
Session: Poster Abstract Session: Global Infections
Thursday, October 5, 2017
Room: Poster Hall CD


Infectious diseases remain a significant healthcare burden in the developing world. In Indonesia, clinicians often manage and treat patients solely based on clinical presentations since the diagnostic testing capacities of hospitals are limited. Unfortunately, the most common infections in this tropical environment share highly similar manifestations, complicating the identification of etiologies and leading to the misdiagnosis of illness. When pathogen-specific testing is available, generally at top-tier specialist hospitals, the limited range of tests and slow turnaround times may never lead to a definitive diagnosis or improved patient outcomes.


To identify clinical parameters that can be used for differentiating the most common causes of fever in Indonesia, we evaluated clinical data from 1,486 acute febrile patients enrolled in a multi-site observational cohort study during 2013 to 2016.


From the 66% of subjects with confirmed etiologies, the six most common infections were dengue virus (455), Salmonella spp. (124), Rickettsia spp. (109), influenza virus (64), Leptospira spp.(53), and chikungunya virus (37). The accompanying figure shows the clinical signs and symptoms (A) and hematology and blood chemistry results (B) for the color-coded pathogens. Comparing the profiles of all infected subjects reveals parameters that are uniquely associated with particular pathogens, such as leukopenia with dengue virus.


These observations will assist clinicians in healthcare systems with limited diagnostic testing capacities and may be useful in formulating diagnostic algorithms for Indonesia and other developing countries.


Herman Kosasih, MD, PhD1, Muhammad Karyana, MD, M.Kes2, Dewi Lokida, MD, Clinical Pathologist3, Bachti Alisjahbana, PhD, SpPD-KPTI4, Emiliana Tjitra, MSc, PhD5, Muhammad Hussein Gasem, Dr., PhD, SpPD-KPTI6, Abu Tholib Aman, MSc, PhD, SpMK (K)7, Ketut Tuti Merati, SpPD-KPTI8, Mansyur Arif, SpPK9, Pratiwi Sudarmono, PhD, SpMK(K)10, Suharto Suharto, MPdk, DTMH, SpPD-KPTI11, Vivi Lisdawati, M.SI, Apt12, Aaron Neal, PhD13 and Sophia Siddiqui, MPH13, (1)Indonesia, Jakarta, Indonesia, (2)National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia, (3)Tangerang General District Hospital, Tangerang, Indonesia, (4)Faculty of Medicine, Hasan Sadikin General Hospital, Bandung, Indonesia, (5)National Institute of Health Research and Development, Ministry of Health, Jakarta, Indonesia, Jakarta, Indonesia, (6)Faculty of Medicine, Diponegoro University, Semarang, Indonesia, (7)Gadjah Mada University, Yogyakarta, Indonesia, (8)Faculty of Medicine Udayana University & Sanglah Hospital, Bali, Indonesia, (9)Dr. Wahidin Soedirohusodo Hospital & Hasanuddin University, Makassar, Indonesia, (10)Cipto Mangunkusumo Hospital, Jakarta, Indonesia, (11)Faculty of Medicine, Airlangga University & Dr. Soetomo Hospital, Surabaya, Indonesia, (12)Sulianti Saroso Hospital, Jakarta, Indonesia, (13)Clinical Research Center, NIAID, National Institutes of Health, Bethesda, United States, Bethesda, MD


H. Kosasih, None

M. Karyana, None

D. Lokida, None

B. Alisjahbana, None

E. Tjitra, None

M. H. Gasem, None

A. T. Aman, None

K. T. Merati, None

M. Arif, None

P. Sudarmono, None

S. Suharto, None

V. Lisdawati, None

A. Neal, None

S. Siddiqui, None

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